{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:16:48Z","timestamp":1784830608480,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T00:00:00Z","timestamp":1120694400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Animal studied\u2002<\/jats:bold>A 6\u2010year\u2010old, pregnant female llama experienced a 6\u2010month history of epiphora, buphthalmos, and acute loss of vision in the left eye. The condition was unresponsive to topical antimicrobial and anti\u2010inflammatory therapy and progressed to corneal rupture.<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>Transpalpebral enucleation was performed and an intraorbital silicone prosthesis was implanted. The eye was fixed in formalin and processed according to routine paraffin technique. Sections of a mass were immunohistochemically prepared routinely and stained for glial fibrillary acidic protein (GFAP), S\u2010antigen, and rhodopsin.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Gross, histopathologic, and immunohistochemical analysis revealed a retinal tumor consistent with a retinoblastoma. The neoplastic tissue formed Flexner\u2013Wintersteiner and Homer\u2013Wright rosettes, originated from the retina, and demonstrated photoreceptor differentiation with S\u2010antigen and rhodopsin expression. Neoplastic cells were negative for GFAP. Four years after enucleation, the llama showed no signs of recurrent neoplasia.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>This report describes the diagnosis and successful treatment of the first known retinoblastoma in a llama.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2005.00407.x","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T20:37:44Z","timestamp":1120768664000},"page":"287-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Retinoblastoma in the eye of a llama (<i>Llama glama<\/i>)"],"prefix":"10.1111","volume":"8","author":[{"given":"Michael 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