{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:33:35Z","timestamp":1763746415497},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T00:00:00Z","timestamp":1105401600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Materials\u2002<\/jats:bold>Ocular and cutaneous tissues from two Japanese Akita dogs with uveodermatologic syndrome (UVD) were subjected to immunohistochemical analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Light microscopic examination of the globes confirmed the presence of panuveitis of different severity in each case. The infiltrate was primarily granulomatous with prominent perivascular lymphoid aggregates. Melanophages were present throughout the affected areas, and there were scattered plasma cells. Immunohistochemistry using CD79a, CD3, MAC387 and MHC class II markers indicated that there were relatively few T lymphocytes and that most lymphocytes were of the B\u2010cell lineage. The two skin biopsies examined also appeared to represent different stages of cutaneous pathology. The biopsy from one case was consistent with the reported features of skin lesions of canine UVD syndrome, including granulomatous dermatitis with extensive T\u2010cell infiltration extending into the epidermis. In contrast, the skin lesion from the second case showed less inflammation, more pigmentary incontinence and evidence of dermal fibrosis. There was no immunoglobulin or complement deposition at any level within the cutaneous or ocular lesions.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The findings of these two cases suggest that the skin lesions of these two dogs with UVD syndrome were mediated by T cells and macrophages (Th1 immunity), whereas the ocular lesions were more consistent with a B cell and macrophage response (Th2 immunity). This is, however, a preliminary investigation and these features may not be the same for all cases of UVD syndrome.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2005.04059.x","type":"journal-article","created":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T18:46:07Z","timestamp":1105469167000},"page":"17-24","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["An immunohistochemical study of uveodermatologic syndrome in two Japanese Akita dogs"],"prefix":"10.1111","volume":"8","author":[{"given":"Wallace J.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Crispin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"445","article-title":"Vogt\u2013Koyanagi\u2013Harada syndrome (uveitis diffusa acuta) in the dog","volume":"673","author":"Asakura S","year":"1977","journal-title":"Japanese Journal of Veterinary Medicine"},{"key":"e_1_2_5_3_2","first-page":"131","article-title":"Granulomatous pan uveitis and dermal depigmentation in dogs","volume":"18","author":"Bussanich MN","year":"1982","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_4_2","first-page":"408","article-title":"Uveitis associated with poliosis and vitiligo in 6 dogs","volume":"187","author":"Kern TJ","year":"1985","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_5_2","first-page":"777","article-title":"Uveodermatological syndrome in an Akita dog","volume":"21","author":"Romatowski J","year":"1985","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_6_2","first-page":"121","article-title":"Generalized leukoderma and poliosis following uveitis","volume":"22","author":"Campbell KL","year":"1986","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1987.tb01445.x"},{"key":"e_1_2_5_8_2","first-page":"1211","article-title":"Vogt\u2013Koyanagi\u2013Harada syndrome in humans and dogs","volume":"11","author":"Morgan RV","year":"1989","journal-title":"Compendium of Small Animal Practice"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1990.tb00093.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700415"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2460\/javma.1992.201.02.313","article-title":"Idiopathic granulomatous disease with ocular adnexal and cutaneous involvement in a dog","volume":"201","author":"Collins BK","year":"1992","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00009.x"},{"key":"e_1_2_5_13_2","first-page":"273","article-title":"Nerve lesion in a Siberian Husky suffering from a uveodermatological syndrome","volume":"35","author":"Denerolle P","year":"2000","journal-title":"Pratique Medicale et Chirurgicale de L\u2019animal de Compagnie"},{"key":"e_1_2_5_14_2","first-page":"27","article-title":"Uveodermatological syndrome in an Akita dog","volume":"31","author":"Zavros NSSM","year":"2001","journal-title":"Australian Veterinary Practitioner"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00925-4"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90129-X"},{"key":"e_1_2_5_17_2","first-page":"289","article-title":"High incidence of Epstein\u2013Barr virus replication in B lymphocytes in Vogt\u2013Hoyanagi\u2013Harada disease","volume":"103","author":"Minoda H","year":"1999","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.7323"},{"key":"e_1_2_5_19_2","first-page":"399","article-title":"Anti\u2010retinal antibodies associated with Vogt\u2013Koyanagi\u2013Harada like syndrome in a dog","volume":"27","author":"Murphy CJ","year":"1991","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050102"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190711"},{"key":"e_1_2_5_22_2","first-page":"23","article-title":"Alternative activation of macrophages. 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