{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:17:59Z","timestamp":1768637879950,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperlipidemic ocular lesions are described for Watanabe heritable hyperlipidemic (WHHL) rabbits. Male WHHL rabbits 8\u00a0months old exhibited serum hyperlipidemia and ophthalmoscopically yellowish\u2010white lesions along the corneoscleral junction and in the iris. Histopathologically, foamy macrophages aggregated in the stroma of the cornea, iris, and ciliary body were observed. These findings have been interpreted as lipid keratopathy. In addition, multiple clusters of a large number of foamy macrophages occurred throughout the choroid and sclera in association with the blood vessels. The lesions in the choroid and sclera could not be detected ophthalmoscopy, yet were much more prominent than those in the cornea, iris, and ciliary body, suggesting greater involvement and earlier onset of lipidosis at these sites associated with hyperlipidemia in WHHL rabbits.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2006.00453.x","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T20:21:19Z","timestamp":1144786879000},"page":"145-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ocular lesions in Watanabe heritable hyperlipidemic rabbits"],"prefix":"10.1111","volume":"9","author":[{"given":"Mami","family":"Kouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinaka","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Horie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim1957.24.3_89"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(80)90234-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(88)90141-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1994.tb04863.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711110407"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050050118030"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90075-X"},{"key":"e_1_2_5_9_2","first-page":"1492","article-title":"Pathogenesis of experimental lipid keratopathy: corneal and plasma lipids","volume":"28","author":"Reddy C","year":"1987","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500214"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00004-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1046404"},{"key":"e_1_2_5_13_2","first-page":"2035","article-title":"Ultrastructural changes in Bruch's membrane of apolipoprotein E\u2010deficient mice","volume":"41","author":"Dithmar S","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_14_2","first-page":"265","article-title":"Accumulation of cholesterol with age in human Bruch's membrane","volume":"42","author":"Curcio CA","year":"2001","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.22.4.258.5501"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2006.00453.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2006.00453.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:25:38Z","timestamp":1696951538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2006.00453.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,11]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1463-5224.2006.00453.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2006.00453.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,11]]},"assertion":[{"value":"2006-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}