{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:33Z","timestamp":1791499533942,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold>To evaluate the efficacy of lamellar resection and adjunctive<jats:sup>90<\/jats:sup>Sr\u2010\u03b2 plesiotherapy in the management of canine limbal melanoma and the frequency and morbidity of early and late\u2010onset side effects following treatment.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>Retrospective study.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Thirty dogs treated for limbal melanoma at the Animal Health Trust (AHT), between 1992 and 2004.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Medical records were reviewed and information collected on the radiation dose administered, duration of follow\u2010up, and the frequency of early\u2010 and late\u2010onset ocular side effects. Follow\u2010up information was obtained by re\u2010examination of patients or completion of a telephone interview with the referring veterinary surgeons or the owners.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Recurrence of limbal melanoma occurred in 1 of 30 cases (3%; 95% CI: 0.2\u201314%). One or more side effects occurred in 16 of 30 cases (53%; 95% CI: 28.1\u201374.9). The occurrence of side effects was not associated with the number of sites treated or the total surface dose of radiation. Short\u2010term side effects were reported in 16\/30 cases (53%) and included corneal scarring (12\/30), corneal neovascularization (6\/30), conjunctivitis with or without granulation tissue formation (5\/30), lipid keratopathy (1\/30), and localized bullous keratopathy (2\/30). Long\u2010term side effects were reported in 6 of 30 cases (20%) cases and included deep scleral thinning (5\/30), focal scleromalacia (3\/30), globe perforation (2\/30), lipid keratopathy (3\/30), localized bullous keratopathy (1\/30), and sectoral cortical cataract (1\/30).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Lamellar resection and adjunctive<jats:sup>90<\/jats:sup>Sr\u2010\u03b2 plesiotherapy is relatively easy to perform, is minimally invasive, and extremely well tolerated by patients. The treatment is highly efficacious in the management of canine limbal melanoma. Modification of the radiation dosimetry, in particular reducing the total dose of radiation and the dose per radiation fraction, is necessary to reduce the incidence of late onset side effects.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2006.00468.x","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T20:21:19Z","timestamp":1144786879000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Canine limbal melanoma: 30 cases (1992\u20132004). Part 2. Treatment with lamellar resection and adjunctive strontium\u201090\u03b2 plesiotherapy \u2013 efficacy and morbidity"],"prefix":"10.1111","volume":"9","author":[{"given":"David","family":"Donaldson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Sansom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"505","article-title":"Use of third eyelid grafts to repair full\u2010thickness defects in the cornea and sclera","volume":"25","author":"Blogg JR","year":"1989","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_3_2","first-page":"83","article-title":"Canine epibulbar melanomas","volume":"17","author":"Martin CL","year":"1981","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03094.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.2460\/javma.1991.198.06.1019","article-title":"Treatment of epibulbar melanocytoma in a dog, using full\u2010thickness eyewall resection and synthetic graft","volume":"6","author":"Wilkie DA","year":"1991","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300411"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2460\/javma.1996.208.06.891","article-title":"Photocoagulation of limbal melanoma dogs and cats: 15 cases (1989\u20131993)","volume":"12","author":"Sullivan TC","year":"1996","journal-title":"Journal of the American Animal Veterinary Medical Association"},{"key":"e_1_2_6_8_2","first-page":"532","volume-title":"Small Animal Clinical Oncology","author":"Miller PE","year":"2001"},{"key":"e_1_2_6_9_2","first-page":"1","volume-title":"Radiotherapy: Principles to Practice \u2013 a Manual for Quality in Treatment Delivery","author":"Griffiths S","year":"1994"},{"key":"e_1_2_6_10_2","first-page":"119","volume-title":"Small Animal Clinical Oncology","author":"LaRue SM","year":"2001"},{"key":"e_1_2_6_11_2","first-page":"1","volume-title":"Basic Clinical Radiobiology","author":"Steel GG","year":"2002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(81)90377-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(84)80074-2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50085-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(50)90445-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2460\/javma.1999.214.02.215","article-title":"Primary corneal papilloma and squamous cell carcinoma associated with pigmentary keratitis in four dogs","volume":"214","author":"Bernays ME","year":"1999","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_17_2","first-page":"56","article-title":"Conjunctival vascular tumours in six dogs","volume":"7","author":"Mughannam AJ","year":"1997","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_6_18_2","first-page":"112","article-title":"Treatment of equine squamous cell carcinoma of the conjunctiva using a strontium 90 applicator","volume":"2","author":"Owen LN","year":"1983","journal-title":"Equine Veterinary Journal of Supplement"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb03759.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30188-8"},{"key":"e_1_2_6_21_2","first-page":"200","article-title":"Ocular angiosarcoma in four horses","volume":"189","author":"Hacker DV","year":"1986","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_22_2","first-page":"182","volume-title":"Basic Clinical Radiobiology","author":"Steel GG","year":"2002"},{"key":"e_1_2_6_23_2","first-page":"399","article-title":"Radiotherapy of epibulbar malignant melanomata","volume":"73","author":"Lederman M","year":"1953","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-29-337-1"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1050941"},{"key":"e_1_2_6_26_2","first-page":"378","article-title":"Beta\u2010ray treatment of conjunctival melanoma","volume":"97","author":"Lommatzsch PK","year":"1977","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00407844"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200206000-00009"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1054331"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30192-X"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.2042-3306.1983.tb04572.x","article-title":"Keratopathy induced by beta radiation therapy in a horse","volume":"2","author":"Moore CP","year":"1983","journal-title":"Equine Veterinary Journal Supplements"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1148\/66.2.240"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.7.496"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2006.00468.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2006.00468.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T18:44:06Z","timestamp":1706985846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2006.00468.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1463-5224.2006.00468.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2006.00468.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,11]]},"assertion":[{"value":"2006-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}