{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:51:07Z","timestamp":1775742667535,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold><jats:bold>Objective\u2002<\/jats:bold>To determine the acute histologic effects of semiconductor diode laser transscleral cyclophotocoagulation (TSCP) on the normal equine eye.<\/jats:p><jats:p><jats:bold>Animal studied\u2002<\/jats:bold>Part 1: eight eyes of four horses. Part 2: 10 eyes of five horses.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold>Part 1: TSCP was performed on four eyes at 4\u00a0mm and four eyes at 6\u00a0mm posterior to the limbus with 15 sites treated in four quadrants at 1800 mW for 1500 ms. The globes were sectioned transversely or sagitally to examine all quadrants and histologic sections were taken every 1\u00a0mm for the entire globe. Part 2: Based on the results from Part 1, TSCP was performed at 20 sites 4\u00a0mm posterior to the dorsotemporal limbus with a constant energy varying from 0.75 to 4\u00a0J\/site. Histologic sections were taken every 1\u00a0mm for a total of 10 sections per eye and 20 sections per energy level group.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Part 1: At 4\u00a0mm posterior to the limbus, coagulation of the nonpigmented epithelium (NPE) of the pars plicata was observed in the temporal (14%) and dorsal quadrants (12%). Retinal detachment was observed in the nasal quadrant (12%). Hemorrhage was common in the nasal (19%) and temporal (12%) quadrants. At 6\u00a0mm posterior to the limbus, coagulation of the NPE of the pars plicata was observed in the dorsal (14%), ventral (16%), nasal (2%), and temporal (2%) quadrants. Retinal detachment was observed in the dorsal (8%), ventral (18%), nasal (20%) and temporal (2%) quadrants. Part 2: Settings of 0.75\u00a0J\/site were ineffective; 1.5, 2.25 and 3\u00a0J\/site damaged the pars plicata without disruption of anatomy; and 4\u00a0J\/site caused disruption of normal architecture.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The most appropriate site for equine TSCP appears to be 4\u00a0mm posterior to the dorso\u2010 and ventrotemporal limbus avoiding the 3 and 9 o\u2019clock positions and using an initial energy setting of 2.25\u00a0J\/site. This results in effective damage to the pars plicata while minimizing surgical complications such as retinal detachment and hemorrhage.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2007.00514.x","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T00:02:44Z","timestamp":1172534564000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Histologic effect of semiconductor diode laser transscleral cyclophotocoagulation on the normal equine eye"],"prefix":"10.1111","volume":"10","author":[{"given":"Raymond J.","family":"Morreale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne J.","family":"Gemensky\u2010Metzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E.","family":"Weisbrode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1053","volume-title":"Veterinary Ophthalmology","author":"Brooks DE","year":"1999"},{"key":"e_1_2_5_3_2","first-page":"151","volume-title":"Veterinary Ophthalmology","author":"Gum GG","year":"1999"},{"key":"e_1_2_5_4_2","first-page":"3145","article-title":"Flow of aqueous humor in humans","volume":"32","author":"Brubaker RF","year":"1991","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_5_2","first-page":"1037","article-title":"Adreno\u2010cholinergic modulation of junctional communications between the pigmented and nonpigmented layers of the ciliary body epithelium","volume":"37","author":"Shi XP","year":"1996","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_6_2","first-page":"1631","volume":"39","author":"McLaughlin CW","year":"1998","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_7_2","first-page":"1853","article-title":"Chloride secretion by bovine ciliary epithelium: a model of aqueous humor formation","volume":"41","author":"Do CW","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_8_2","first-page":"170","article-title":"Equine glaucoma: clinical findings and response to treatment in 14 horses","volume":"5","author":"Miller TR","year":"1995","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_9_2","first-page":"701","volume-title":"Veterinary Ophthalmology","author":"Gelatt KN","year":"1999"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800110"},{"key":"e_1_2_5_11_2","first-page":"105","article-title":"Congenital equine glaucoma: clinical and light microscopic findings in two cases","volume":"7","author":"Marrion\u2010Halenda R","year":"1997","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_12_2","first-page":"756","article-title":"Equine glaucoma: a retrospective study of 11 cases from 1988 to 1993","volume":"88","author":"Pickett JP","year":"1993","journal-title":"Veterinary Medicine"},{"key":"e_1_2_5_13_2","first-page":"470","article-title":"Equine glaucoma: a retrospective study of 13 cases presented at the Western College of Veterinary Medicine from 1992 to 1999","volume":"41","author":"Cullen CL","year":"2000","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_14_2","unstructured":"WilkieDA PeckhamES PaulicSet al.Equine glaucoma and diode laser transscleral cyclophotocoagulation: 27 cases (abstract).32nd Annual Meeting of the American College of Veterinary Ophthalmologists2001:50."},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30441-8"},{"key":"e_1_2_5_16_2","first-page":"1884","article-title":"Equine tonometry","volume":"156","author":"Cohen CM","year":"1970","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2460\/javma.1992.201.03.430","article-title":"Comparison of applanation tonometers in dogs and horses","volume":"201","author":"Dziezyc J","year":"1992","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2460\/ajvr.1990.51.06.935","article-title":"Evaluation of two applanation tonometers in horses","volume":"51","author":"Miller PE","year":"1990","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2460\/ajvr.1995.56.02.155","article-title":"Effect of auriculopalpebral nerve block and intravenous administration of xylazine on intraocular pressure and corneal thickness in horses","volume":"56","author":"Van der Woerdt A","year":"1995","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080110070037"},{"key":"e_1_2_5_21_2","first-page":"147","article-title":"Contact transcleral cyclophotocoagulation using a neodyium: ytrrium aluminum garnet laser in normal dogs","volume":"2","author":"Sapienza JS","year":"1992","journal-title":"Progress in Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_22_2","first-page":"1972","article-title":"Neodymium: yttrium, aluminum, and garnet laser energy delivered transclerally to the ciliary body of dogs","volume":"49","author":"Nasisse MP","year":"1988","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2460\/javma.1990.197.03.350","article-title":"Treatment of glaucoma by use of transscleral neodymium: yttrium aluminum garnet laser cyclophotocoagulation in dogs","volume":"197","author":"Nasisse MP","year":"1990","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2460\/javma.1999.215.10.1469","article-title":"Combined cycloablasion and gonioimplantation for the treatment of glaucoma in dogs: 18 cases (1992\u20131998)","volume":"215","author":"Bentley E","year":"1999","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_25_2","first-page":"148","article-title":"Diode laser transscleral cyclophotocoagulation for the treatment of glaucoma in dogs: results of six and twelve month follow\u2010up","volume":"7","author":"Cook C","year":"1997","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00178.x"},{"key":"e_1_2_5_27_2","first-page":"45","article-title":"The effects of continuous wave Nd:YAG and semiconductor diode laser energy on the canine ciliary body: in vitro thermographic analysis","volume":"6","author":"Quinn RF","year":"1996","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_28_2","first-page":"155","article-title":"Clinical and histopathologic effect of diode laser transcleral cyclophotocoagulation in the normal canine eye","volume":"7","author":"Nadelstein B","year":"1997","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689509033523"},{"key":"e_1_2_5_30_2","first-page":"2029","article-title":"Cyclocryotherapy and noncontact Nd:YAG laser cyclophotocoagulation in cats","volume":"37","author":"Rosenberg LF","year":"1996","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00083.x"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070100108044"},{"key":"e_1_2_5_33_2","first-page":"1586","article-title":"Histopathology of continuous wave neodymium: yttrium aluminum garnet and diode laser contact transscleral lesions in rabbit ciliary body: a comparative study","volume":"32","author":"Brancato R","year":"1991","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00889-2"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32550-2"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31846-9"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30794-4"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090040080035"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75758-7"},{"key":"e_1_2_5_40_2","first-page":"2216","article-title":"Inflammatory effects of continuous\u2010wave neodymium: yttrium aluminum garnet laser cyclophotocoagulation","volume":"33","author":"Nasisse MP","year":"1992","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_41_2","first-page":"1114","article-title":"Early tissue response to transscleral neoydium:YAG cyclophotocoagulation","volume":"31","author":"Blasini M","year":"1991","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(05)90001-8"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1996.0119"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50105-7"},{"key":"e_1_2_5_45_2","first-page":"170","article-title":"Retinal detachment as a complication of neodymium:yttrium aluminum garnet laser cyclophotocoagulation","volume":"25","author":"Geyer O","year":"1993","journal-title":"Annals of Ophthalmology"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00175-5"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71911-7"},{"key":"e_1_2_5_48_2","first-page":"1","volume-title":"Laser Therapy in Glaucoma","author":"Beckman H","year":"1985"},{"key":"e_1_2_5_49_2","first-page":"12","volume-title":"Photocoagulation in Glaucoma and Anterior Segment Disease.","author":"Belcher CD","year":"1984"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900170203"},{"key":"e_1_2_5_51_2","first-page":"3032","article-title":"Intraocular photodisruption with picosecond and nanosecond laser pulses: tissue effects in cornea, lens, and retina","volume":"35","author":"Vogel A","year":"1994","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900150106"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91781-9"},{"key":"e_1_2_5_54_2","first-page":"2774","article-title":"A comparison of neodymium: yttrium aluminum garnet and diode laser transscleral cyclophotocoagulation and cyclocryotherapy","volume":"32","author":"Assia EI","year":"1991","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00147.x"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2007.00514.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2007.00514.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T07:19:01Z","timestamp":1707635941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2007.00514.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,26]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1463-5224.2007.00514.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2007.00514.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,26]]},"assertion":[{"value":"2007-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}