{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:02:57Z","timestamp":1790611377618,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T00:00:00Z","timestamp":1176422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To describe and characterize histiocytic sarcoma (HS) first detected in the eyes of dogs using the large database at the comparative ocular pathology laboratory of Wisconsin (COPLOW).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Cases diagnosed as HS were selected from the COPLOW database. Slides were reviewed to describe the cellular morphology, localize the tumor within the globe, record the tumor distribution and measure the size of the tumor. Further sections were taken to perform immunohistochemistry for Melan\u2010A, CD18 and S\u2010100, and for ferric iron staining. The following clinical information was recorded: breed, age, gender, laterality, clinical signs upon presentation and follow\u2010up information obtained by response to a mailed survey and phone contact.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Twenty\u2010six cases were confirmed as being HS according to the immunohistochemical results (CD18 positive and Melan\u2010A negative). The most prevalent breed was Rottweiler (eight cases), followed by Retriever breeds (seven Golden Retrievers and five Labrador Retrievers). The mean age was 8.61\u00a0\u00b1\u00a02.43\u00a0years. There were three intact male, eight castrated male, one intact female and 14 spayed female dogs. In 15 dogs there were no concurrent systemic clinical signs at the time of diagnosis. Sixteen of 19 dogs with follow\u2010up information available died as a result of causes related to the tumor, although only three of them received a necropsy. Survival time varied between 5\u00a0days and 6\u00a0months after enucleation. Three of the dogs were alive at the time the information was gathered. Mean tumor surface was 0.613\u00a0\u00b1\u00a00.38\u00a0cm<jats:sup>2<\/jats:sup>. S\u2010100 was diffusely positive in 10 cases, isolated positive cells were found in 11 cases and five cases were completely negative. Seven of the cases were positive for ferric iron.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>Histiocytic sarcoma must be considered in the differential diagnosis of dogs with intraocular masses, especially in Rottweilers and Retriever breeds. Because it carries poor prognosis, it must be distinguished from melanoma. A good discriminator for this purpose in paraffin\u2010embedded tissues is finding CD18\u2010positive cells and no reactivity against Melan\u2010A. S\u2010100 and ferric iron staining does not seem to be useful. Ocular HS is considered to be a manifestation of a systemic disease even when the disease is first recognized in the eye.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2007.00534.x","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T16:55:16Z","timestamp":1177952116000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Canine ocular histiocytic sarcoma"],"prefix":"10.1111","volume":"10","author":[{"given":"Carolina","family":"Naranjo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen R.","family":"Friedrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"588","volume-title":"Kirk's Current Veterinary Therapy","author":"Affolter VK","year":"2000"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch3"},{"key":"e_1_2_6_5_2","unstructured":"ValliVE JacobsRM ParodiALet al.Solid myeloid proliferations. In:WHO Histological Classification of Hematopoietic Tumors of Domestic Animals 2nd series Vol. III.Armed Forces Institute of Pathology Washington D.C. 2002;58\u201361."},{"key":"e_1_2_6_6_2","first-page":"305","article-title":"Histiocytoma of the eyelid of a dog","volume":"70","author":"Gelatt KN","year":"1975","journal-title":"Veterinary Medicine: Small Animal Clinician"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100602"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2460\/javma.1992.201.08.1229","article-title":"Ocular manifestation of systemic histiocytosis in a dog","volume":"201","author":"Scherlie PH","year":"1992","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02905.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300109"},{"key":"e_1_2_6_11_2","first-page":"919","article-title":"Malignant histiocytosis in four dogs","volume":"187","author":"Wellman ML","year":"1985","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_12_2","first-page":"1041","article-title":"Malignant histiocytosis in Bernese Mountain dogs","volume":"188","author":"Rosin A","year":"1986","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589303000306"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.138.18.440"},{"key":"e_1_2_6_15_2","first-page":"1699","article-title":"Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2\u2010integrin molecules","volume":"148","author":"Moore PF","year":"1996","journal-title":"American Journal of Pathology"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200002000-00009"},{"key":"e_1_2_6_17_2","first-page":"1072","article-title":"\u2018Histiocytic markers\u2019 in melanoma","volume":"12","author":"Pernick NL","year":"1999","journal-title":"Modern Pathology"},{"key":"e_1_2_6_18_2","first-page":"147","volume-title":"Diagnostic Immunohistochemistry","author":"Wick MR","year":"2002"},{"key":"e_1_2_6_19_2","first-page":"505","volume-title":"Kirk's Current Veterinary Therapy","author":"Moore PF","year":"2000"},{"key":"e_1_2_6_20_2","first-page":"327","article-title":"Inheritance of histiocytosis in Bernese mountain dogs","volume":"31","author":"Padgett GA","year":"1995","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_6_21_2","first-page":"755","volume-title":"Veterinary Ophthalmology","author":"Collins BK","year":"1999"},{"key":"e_1_2_6_22_2","first-page":"1064","article-title":"Hyphema. Part I. Pathophysiologic considerations","volume":"21","author":"Komaromy AM","year":"1999","journal-title":"Compendium on Continuing Education for the Practicing Veterinarian"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00217.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376904.ch11"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300615"},{"key":"e_1_2_6_27_2","first-page":"313","volume-title":"Diagnostic Immunohistochemistry","author":"Helm KF","year":"2002"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01952.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-4-437"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-6-651"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-6-713"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-597"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-4-427"},{"key":"e_1_2_6_34_2","first-page":"3","volume-title":"Diagnostic Immunohistochemistry","author":"Taylor CR","year":"2002"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-4-405"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2007.00534.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2007.00534.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T01:00:18Z","timestamp":1707872418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2007.00534.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,13]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1463-5224.2007.00534.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2007.00534.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,13]]},"assertion":[{"value":"2007-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}