{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:11:40Z","timestamp":1770747100141,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To evaluate the success of the use of systemic corticosteroids and antifungal medications in the treatment of dogs with ocular lesions associated with systemic blastomycosis.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>Retrospective study.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Medical records of 25 dogs diagnosed with blastomycosis, via either cytology or histopathology, at the Purdue University Veterinary Teaching Hospital between 1 January 2000 and 1 January 2005, were reviewed.<\/jats:p><jats:p><jats:bold>Procedure\u2002<\/jats:bold>Data collected from the medical records included signalment, presence and progression of ocular lesions, antifungal drugs administered, oral and topical corticosteroid administration, length of follow\u2010up, response to treatment, and visual outcome.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Of the 25 cases reviewed, 12 dogs (19 eyes) with follow\u2010up information were found to have lesions consistent with ocular blastomycosis. Length of follow\u2010up in the 12 cases ranged from 1\u00a0month to 31\u00a0months with a mean of 9\u00a0months. Antifungal therapy for all cases consisted of oral itraconazole (5\u00a0mg\/kg every 24\u00a0h) initially. In seven cases, the antifungal drug administered was changed from itraconazole to oral fluconazole. Two of these also received intravenous amphotericin B, and two received additional treatment with itraconazole. All 12 dogs also received oral prednisone. The dose of oral prednisone utilized ranged from 0.2\u00a0mg\/kg\/day to 1.4\u00a0mg\/kg\/day with a mean of 0.7\u00a0mg\/kg\/day; the duration of oral prednisone administration ranged from 2\u00a0weeks to 8.5\u00a0months with a mean of 3\u00a0months. Topical prednisolone was a component of the treatment of 16 of the 19 eyes. Duration of topical prednisolone treatment ranged from 1\u00a0month to 30\u00a0months with a mean of 5\u00a0months. Lesions not located in the eyes exhibited a positive response to treatment in 11 (92%) of the 12 dogs. Overall, 14\/19 (74%) affected eyes were visual at the time of their final recheck. All eyes with mild or moderate lesions and 5\/10 (50%) severely affected eyes were visual at their last recorded recheck examination.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The administration of systemic corticosteroids did not appear to adversely affect the survival rate and might have played a role in preservation of vision in a majority of dogs in this group with ocular blastomycosis.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2007.00554.x","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T10:55:54Z","timestamp":1187952954000},"page":"299-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Visual outcome in a group of dogs with ocular blastomycosis treated with systemic antifungals and systemic corticosteroids"],"prefix":"10.1111","volume":"10","author":[{"given":"Michael J.","family":"Finn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Stiles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl G.","family":"Krohne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"569","volume-title":"Infectious Diseases of the Dog and Cat","author":"Legendre AM","year":"2006"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2460\/javma.1998.213.05.658","article-title":"Blastomycosis in dogs: 115 cases (1980\u20131995)","volume":"213","author":"Arceneaux KA","year":"1998","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_4_2","first-page":"1163","article-title":"Canine blastomycosis: a review of 47 clinical cases","volume":"178","author":"Legendre AM","year":"1981","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_5_2","first-page":"671","volume-title":"Textbook of Veterinary International Medicine. 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