{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:36:07Z","timestamp":1788568567436,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T00:00:00Z","timestamp":1303084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To describe the clinical phenotype and genetics of equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in<jats:italic>PMEL17<\/jats:italic>(<jats:italic>Silver<\/jats:italic>) mutant ponies.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Five presumably unrelated ponies.<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>The ponies were examined under field conditions in their barn by slit lamp biomicroscopy, indirect ophthalmoscopy, and applanation tonometry. Blood was collected and genomic DNA extracted for<jats:italic>MCOA<\/jats:italic>genotyping using the<jats:italic>PMEL17ex11<\/jats:italic>marker.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>One pony solely presented with temporal ciliary body cysts, suggestive of the less severe<jats:italic>Cyst<\/jats:italic>phenotype of MCOA; the animal was heterozygous at the<jats:italic>MCOA<\/jats:italic>locus. Multiple bilateral anterior segment anomalies were identified in four ponies, consistent with the more severe<jats:italic>MCOA<\/jats:italic>phenotype characterized by cornea globosa, iris hypoplasia, encircling granula iridica along the pupillary ruff, and cataracts. These animals were homozygous for the mutant<jats:italic>MCOA<\/jats:italic>allele. Four of the ponies had a silver dapple or chocolate coat color with white or flaxen manes and tails. Silver dappling was masked by the palomino coloring of a 5th pony that was homozygous at the<jats:italic>MCOA<\/jats:italic>locus.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>The MCOA syndrome can be seen in ponies. The results of both clinical evaluation and genotyping resembled the previously described MCOA of both Rocky Mountain and Kentucky Mountain Saddle horses.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00878.x","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T04:01:37Z","timestamp":1303185697000},"page":"313-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in<i>PMEL17<\/i>(<i>Silver<\/i>) mutant ponies: five cases"],"prefix":"10.1111","volume":"14","author":[{"given":"Andr\u00e1s M.","family":"Kom\u00e1romy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Rowlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle C.","family":"La 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