{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T09:10:02Z","timestamp":1741165802347,"version":"3.38.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T00:00:00Z","timestamp":1303776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To perform a randomized, placebo\u2010controlled, masked clinical trial using a cross\u2010over design to determine the effect of oral diphenhydramine on aqueous tear production in normal dogs.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Seventeen dogs with normal ophthalmic examinations.<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>Baseline tear production was established for each dog by performing Schirmer tear test I (STT I). Dogs received 20\u2010day treatment courses of both oral diphenhydramine and placebo solutions with a 10\u2010day washout period between treatment periods. Each dog was randomly assigned to receive diphenhydramine or placebo at the outset of the study. Measurements of STT I values were measured at regular intervals during the study and were conducted at the same time of day throughout the study to control for diurnal variations in tear production. The significance of the impact of diphenhydramine treatment on the quantity of aqueous tear production, as determine by STT results over time, was evaluated using regression analysis with appropriate transformation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Statistical comparisons at each measurement time, including baseline measurements between control and treatment groups, revealed no significant differences. Mean STT I levels also did not differ significantly at any measurement time compared to baseline for treatment or control groups.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Short\u2010term administration of oral diphenhydramine does not result in a significant decrease in aqueous tear production in normal dogs.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00897.x","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T06:06:31Z","timestamp":1303797991000},"page":"395-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of short\u2010term diphenhydramine administration on aqueous tear production in normal dogs"],"prefix":"10.1111","volume":"14","author":[{"given":"Keith W.","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Ledbetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussni O.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"288","volume-title":"Veterinary Ophthalmology","author":"Regnier A","year":"2007"},{"key":"e_1_2_5_3_2","first-page":"88","article-title":"Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992\u20131998)","volume":"3","author":"Zur G","year":"2002","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00285.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.8.241"},{"key":"e_1_2_5_6_2","first-page":"830","article-title":"A survey of canine and feline skin disorders seen in a university practice: Small Animal Clinic, University of Montreal, Saint\u2010Hyacinthe, Quebec (1987\u20131988)","volume":"31","author":"Scott DW","year":"1990","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408390591001117"},{"key":"e_1_2_5_8_2","first-page":"5","article-title":"The tear film in the dog. 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