{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:10:52Z","timestamp":1790626252118,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine if congenital stationary night blindness (CSNB) exists in the miniature horse in association with leopard complex spotting patterns (<jats:italic>LP<\/jats:italic>), and to investigate if CSNB in the miniature horse is associated with three single nucleotide polymorphisms (SNPs) in the region of <jats:italic>TRPM1<\/jats:italic> that are highly associated with CSNB and <jats:italic>LP<\/jats:italic> in Appaloosas.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold> Three groups of miniature horses were studied based on coat patterns suggestive of <jats:italic>LP\/LP<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2003=\u20033), <jats:italic>LP\/lp<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2003=\u20034), and <jats:italic>lp\/lp<\/jats:italic> genotype (<jats:italic>n<\/jats:italic>\u2003=\u20034).<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold> Horses were categorized based on phenotype as well as pedigree analysis as <jats:italic>LP\/LP<\/jats:italic>, <jats:italic>LP\/lp<\/jats:italic>, and <jats:italic>lp\/lp<\/jats:italic>. Neurophthalmic examination, slit\u2010lamp biomicroscopy, indirect ophthalmoscopy, and scotopic flash electroretinography were performed on all horses. Hair samples were processed for DNA analysis. Three SNPs identified and associated with <jats:italic>LP<\/jats:italic> and CSNB in the Appaloosa were investigated for association with <jats:italic>LP<\/jats:italic> and CSNB in these Miniature horses.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> All horses in the <jats:italic>LP\/LP<\/jats:italic> group were affected by CSNB, while none in the <jats:italic>LP\/lp<\/jats:italic> or <jats:italic>lp\/lp<\/jats:italic> groups were affected. All three SNPs were completely associated with <jats:italic>LP<\/jats:italic> genotype (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u200322, <jats:italic>P<\/jats:italic>\u2003&lt;&lt;\u20030.0005) and CSNB status (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u200311, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0005).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The Miniature Horse breed is affected by CSNB and it appears to be associated with <jats:italic>LP<\/jats:italic> as in the Appaloosa breed. The SNPs tested could be used as a DNA test for CSNB until the causative mutation is determined.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00903.x","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T04:26:54Z","timestamp":1303187214000},"page":"18-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Congenital stationary night blindness is associated with the leopard complex in the miniature horse"],"prefix":"10.1111","volume":"15","author":[{"given":"Lynne S.","family":"Sandmeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca 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