{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:58:18Z","timestamp":1769097498719,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T00:00:00Z","timestamp":1316131200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To determine the extent of fluctuation in circadian intraocular pressure (IOP) and the efficacy of topical dorzolamide 2% q 8\u2003h in lowering IOP and blunting circadian fluctuation in IOP in glaucomatous cats.<\/jats:p><jats:p><jats:bold>Animals studied\u2002<\/jats:bold>Seven adult cats with primary congenital glaucoma (PCG).<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>Measurements of IOP and pupil diameter were obtained for both eyes (OU) of each cat q 4\u2003h for 12\u2003days. Cats were housed in a laboratory animal facility with a 12\u2010h light:dark cycle. Baseline values were established for 2\u2003days. For the next 5\u2003days, placebo (1.4% polyvinyl alcohol) was administered OU q 8\u2003h. Dorzolamide 2% was then administered OU q 8\u2003h for a further 5\u2003days. A multivariate mixed linear model was fitted to the data, with parameters estimated from a Bayesian perspective. The 4\u2003<jats:sc>am<\/jats:sc>time point was selected as the reference for the purposes of comparisons.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Estimated mean IOP for the reference time point pre\u2010treatment was symmetric (about 33\u2003mmHg OU). In all cats, IOP was significantly lower during the diurnal phase, relative to the 4\u2003<jats:sc>am<\/jats:sc>measurements, with highest IOP observed 2\u20136\u2003h after the onset of the dark phase. Circadian fluctuations in IOP were dampened during the treatment period. There was a significant decrease in IOP in all cats during the dorzolamide treatment period (estimated mean for the treatment period reference\u2003=\u200317.9\u2003mmHg OU).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Topical dorzolamide 2% q 8\u2003h is effective in reducing IOP and IOP fluctuation in cats with PCG.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00913.x","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T19:32:17Z","timestamp":1316201537000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma"],"prefix":"10.1111","volume":"14","author":[{"given":"Kelly 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