{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:04:00Z","timestamp":1788037440764,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T00:00:00Z","timestamp":1316131200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the effects of topical 0.5% tropicamide on anterior segment morphology (ASM) and intraocular pressure (IOP) in normal and glaucomatous cats.<\/jats:p><jats:p><jats:bold>Animals used\u2002<\/jats:bold> Normal cats and cats with inherited primary congenital glaucoma (PCG).<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold> Control IOP curves were performed in untreated normal and PCG cats. In the first experiment, tropicamide was applied OD in eight normal and nine PCG cats. IOP and pupillary diameter (PD) were measured at 0, 30, and 60\u2003min, then hourly until 8\u2003h post\u2010treatment. In a second experiment, six normal and seven PCG cats received tropicamide OD. High\u2010resolution ultrasound images were obtained at 0, 1, 5, and 10\u2003h post\u2010treatment to measure ASM changes. IOP and PD were measured OD at 0, 1, 2, 3, 5, 7, and 9\u2003h.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In untreated normal cats IOP OU decreased throughout the day. In PCG cats IOP OU had wide fluctuations over time. In normal cats IOP response varied in the treated eye but did not change significantly in untreated eyes. IOP significantly increased from baseline in both eyes of all treated PCG cats. Increases in IOP were associated with some ASM changes. Cats with PCG had a significantly smaller angle recess areas, diminished ciliary clefts and decreased iris\u2010lens contact. ASM changes were not strongly correlated with IOP in all cats.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The ASM of PCG cats is markedly different from normal cats, and clinically significant increases in IOP OU occur in cats with PCG after tropicamide treatment. The mechanism for this increase remains unclear.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00927.x","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T19:32:17Z","timestamp":1316201537000},"page":"75-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of unilateral topical administration of 0.5% tropicamide on anterior segment morphology and intraocular pressure in normal cats and cats with primary congenital glaucoma"],"prefix":"10.1111","volume":"14","author":[{"given":"Filipe","family":"Espinheira Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellison","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian J.","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1994.10.431"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.01840020634005"},{"key":"e_1_2_6_4_2","first-page":"43","article-title":"Bis\u2010tropamide, a new parasympatholytic","volume":"2","author":"Merrill DLGD","year":"1960","journal-title":"Current Therapeutic Research"},{"key":"e_1_2_6_5_2","first-page":"206","article-title":"Acute, transient sialoadenomegaly in two cats following topical administration of tropicamide","volume":"7","author":"Willis M","year":"1997","journal-title":"Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_6_6_2","first-page":"283","article-title":"Evaluation of mydriatics in the cat","volume":"9","author":"Gelatt KN","year":"1973","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00226.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00474.x"},{"key":"e_1_2_6_9_2","unstructured":"McLellanGJ KuehnM SigleK.Effect of topical 1% tropicamide on intraocular pressure in cats with primary congenital glaucoma. 36th Annual Meeting of the American College of Veterinary Ophthalmologists2005; 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