{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:36:18Z","timestamp":1773243378625,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T00:00:00Z","timestamp":1317945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Equine recurrent uveitis (ERU) is a spontaneous disease that is the most common cause of blindness in horses, affecting up to 15% of the horse population. Th17 cells are a major cell population driving the pathogenesis in several mouse models of autoimmune inflammation, including experimental autoimmune uveitis. The purpose of this study is to investigate the role a Th17 cell\u2010mediated response plays in the pathogenesis of ERU.<\/jats:p><jats:p><jats:bold>Procedure\u2002<\/jats:bold> Banked, Davidson\u2019s\u2010fixed equine globes histopathologically diagnosed with ERU (<jats:italic>n<\/jats:italic>\u2003=\u20037) were compared immunohistochemically with healthy control globes (<jats:italic>n<\/jats:italic>\u2003=\u20037). Immunohistochemical staining was performed using a pan\u2010<jats:italic>Leptospira<\/jats:italic> antibody and antibodies against IL\u20106, IL\u201017, and IL\u201023. Additionally, immunostaining was performed for T\u2010cell (CD3) and B\u2010cell (CD79\u03b1) markers. Specificity of immunoreactivity was confirmed by western blot analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Immunohistochemical staining was positive for IL\u20106, IL\u201017, and IL\u201023 within the cytoplasm of nonpigmented ciliary epithelial cells and mononuclear inflammatory cells infiltrating the iris, and ciliary body of ERU horses (<jats:italic>n<\/jats:italic>\u2003=\u20037) but negative in controls (<jats:italic>n<\/jats:italic>\u2003=\u20037). ERU\u2010affected eyes were CD3 positive (<jats:italic>n<\/jats:italic>\u2003=\u20037) and CD79\u03b1 negative (<jats:italic>n<\/jats:italic>\u2003=\u20037). Staining for <jats:italic>Leptospira<\/jats:italic> was negative in all ERU and control globes.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Strong immunoreactivity for IL\u20106, IL\u201017, and IL\u201023, in conjunction with the fact that T lymphocytes are the predominating inflammatory cells present in ERU, suggests that IL\u201017\u2010secreting helper T\u2010cells play a role in the pathogenesis of ERU. These findings suggest that horses with ERU may serve as a naturally occurring animal model for autoimmune uveitis.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00951.x","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T21:11:18Z","timestamp":1318021878000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Characterization of cytokines associated with Th17 cells in the eyes of horses with recurrent uveitis"],"prefix":"10.1111","volume":"15","author":[{"given":"Daniel P.","family":"Regan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan C.","family":"Aarnio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley S.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Paige","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel L.","family":"Vandenplas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Lauderdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip A.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"126","article-title":"[Equine recurrent uveitis]","volume":"139","author":"Spiess BM","year":"1997","journal-title":"Schweizer Archiv fur Tierheilkunde"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9846(17)30006-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00625.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.10.1329"},{"key":"e_1_2_6_6_2","first-page":"418","article-title":"[Detection of leptospira in the vitreous body of horses without ocular diseases and of horses with equine recurrent uveitis (ERU) using transmission\u2010electron microscopy]","volume":"113","author":"Niedermaier G","year":"2006","journal-title":"DTW. 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