{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:48:54Z","timestamp":1774313334677,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T00:00:00Z","timestamp":1317254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a report of dendritic ulcerative keratitis in a 4\u2010year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus\u20101 (CHV\u20101) infection. The dog was presented for evaluation of mild blepharospasm and conjunctival hyperemia in the right eye (OD) shortly after attending a public boarding facility. For approximately 3\u2003months, the dog had been receiving topical prednisolone acetate 1.0% and tacrolimus 0.02% in both eyes (OU) q12h for treatment of follicular conjunctivitis. Ophthalmic examination revealed three regions of corneal fluorescein retention OD. The lesions had a dendritic pattern, were approximately 2\u20133\u2003mm in length, and were located at the dorsomedial, lateral, and ventromedial aspects of the cornea. No additional abnormalities were noted on complete ophthalmic and physical examinations. CHV\u20101 was identified in conjunctival samples OD by polymerase chain reaction, and paired CHV\u20101 serum virus neutralization antibody titers were positive and consistent with acute infection. Topical prednisolone acetate and tacrolimus were discontinued. The dog was treated with cidofovir 0.5% OU q12h for a period of 4\u2003weeks, with resolution of corneal disease noted within 1\u2003week of treatment. In conjunction with previous studies, this case report supports a central role for alterations in host immune status in the pathogenesis and clinical manifestations of CHV\u20101 ocular disease in dogs.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00952.x","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T10:48:43Z","timestamp":1317379723000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Acute primary canine herpesvirus\u20101 dendritic ulcerative keratitis in an adult dog"],"prefix":"10.1111","volume":"15","author":[{"given":"Kristen J.","family":"Gervais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Pirie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Ledbetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pizzirani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,29]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-1-37"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2004.11.016"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050391"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(98)00285-5"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-7-1601"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10425179709034057"},{"key":"e_1_2_4_8_2","first-page":"803","article-title":"Clinical and pathologic features of a fatal viral disease of newborn pups","volume":"26","author":"Carmichael LE","year":"1965","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_4_9_2","first-page":"610","article-title":"Experimental transplacental transmission of canine herpesvirus in pregnant bitches during the second trimester of gestation","volume":"44","author":"Hashimoto A","year":"1983","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_4_10_2","first-page":"669","article-title":"Genital disease in dogs caused by canine herpesvirus","volume":"35","author":"Hill H","year":"1974","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_4_11_2","first-page":"1251","article-title":"Experimental production of canine tracheobronchitis (kennel cough) with canine herpesvirus isolated from naturally infected dogs","volume":"29","author":"Karpas A","year":"1968","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.45.123"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(96)01227-8"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.61.375"},{"key":"e_1_2_4_15_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2460\/ajvr.1993.54.04.551","article-title":"Virus reactivation in bitches with a medical history of herpesvirus infection","volume":"54","author":"Okuda Y","year":"1993","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2001.0110"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.001"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00709.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.3.376"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.4.513"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.03.013"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.8.954"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199903000-00002"},{"key":"e_1_2_4_24_2","first-page":"1758","article-title":"Experimental ocular herpesvirus infection in the cat. 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