{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:08:26Z","timestamp":1764493706567},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T00:00:00Z","timestamp":1326326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold> Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non\u2010Hodgkin\u2019s and Hodgkin\u2019s lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A 1\u2010year\u2010old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work\u2010up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200\u2003km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00981.x","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T05:08:06Z","timestamp":1326431286000},"page":"345-350","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Uveodermatologic lymphoma in two young related Portuguese water dogs"],"prefix":"10.1111","volume":"15","author":[{"given":"Nat\u00e0lia","family":"Escanilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Leiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ordeix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,12]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"150","volume-title":"Tumors in Domestic Animals","author":"Moulton JE","year":"1978"},{"key":"e_1_2_4_3_2","volume-title":"Withrow & MacEwen\u2019s Small Animal Clinical Oncology","author":"Vail DM","year":"2007"},{"key":"e_1_2_4_4_2","first-page":"392","volume-title":"Veterinary Cancer Medicine","author":"Madewell BR","year":"1987"},{"key":"e_1_2_4_5_2","first-page":"127","article-title":"Prevalence of ocular involvement in dogs with multicentric lymphoma: prospective evaluation of 94 cases","volume":"4","author":"Krohne SG","year":"1994","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_4_6_2","first-page":"493","article-title":"Ocular changes in malignant lymphoma of dogs","volume":"52","author":"Cello RM","year":"1962","journal-title":"Cornell Veterinary"},{"key":"e_1_2_4_7_2","first-page":"835","article-title":"Intraocular tumors in animals. 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