{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:03:03Z","timestamp":1777420983441,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical presentation and progression (over 9\u2003months to 13\u2003years) of congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID) in the Cavalier King Charles spaniel dog are described for six new cases and six previously described cases. Cases presented with a congenitally abnormal (rough\/curly) coat and signs of KCS from eyelid opening. Persistent scale along the dorsal spine and flanks with a harsh frizzy and alopecic coat was evident in the first few months of life. Ventral abdominal skin was hyperpigmented and hyperkeratinized in adulthood. Footpads were hyperkeratinized from young adulthood with nail growth abnormalities and intermittent sloughing. Long\u2010term follow\u2010up of cases (13\/25) is described. Immunomodulatory\/lacrimostimulant treatment had no statistically significant effect on Schirmer tear test results, although subjectively, this treatment reduced progression of the keratitis. Histopathological analysis of samples (skin\/footpads\/lacrimal glands\/salivary glands) for three new cases was consistent with an ichthyosiform dermatosis, with no pathology of the salivary or lacrimal glands identified histologically. Pedigree analysis suggests the syndrome is inherited by an autosomal recessive mode.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2011.00986.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T03:26:26Z","timestamp":1325215586000},"page":"315-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs \u2013 part I: clinical signs, histopathology, and inheritance"],"prefix":"10.1111","volume":"15","author":[{"given":"Claudia","family":"Hartley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Henley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom W.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Blott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathryn","family":"Mellersh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith C.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"577","article-title":"Ichthyoses \u2013 Part 2: congenital ichthyoses","volume":"7","author":"Krug M","year":"2009","journal-title":"Journal of the German Society of Dermatology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800002-JLR200"},{"key":"e_1_2_6_4_2","first-page":"349","article-title":"Ichthyoses: differential diagnosis and molecular genetics","volume":"16","author":"Oji V","year":"2006","journal-title":"European Journal of Dermatology"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07806.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.6.465"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5493.947"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_6_9_2","first-page":"81","article-title":"Ichthyoses: etiology, diagnosis and management","volume":"4","author":"Diovanna JJ","year":"2003","journal-title":"American Journal of Clinical Dermatology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2003.11.003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00667.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09161.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1994.tb00023.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1997.tb00264.x"},{"key":"e_1_2_6_15_2","first-page":"529","volume-title":"Advances in Veterinary Dermatology","author":"Credille K","year":"1998"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.96"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-6-751"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2460\/javma.1990.197.06.764","article-title":"Congenital ichthyosis in a llama","volume":"197","author":"Belknap EB","year":"1990","journal-title":"Journal of American Veterinary Medicine Association"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00565.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/oxfordjournals.jhered.a108979","article-title":"Infantile ichthyosis in rats: a new model of hyperkeratotic skin disease","volume":"69","author":"Knox WE","year":"1978","journal-title":"Journal of Heredity"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285392"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1935(85)90120-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06735.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00107.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1422"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0127"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00437.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2460\/ajvr.1985.46.02.376","article-title":"Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases","volume":"46","author":"Kaswan RL","year":"1985","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199811000-00014"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8011-8"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-9-114"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.22.5.382"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00597.x"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2011.00986.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2011.00986.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:36:44Z","timestamp":1742182604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2011.00986.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,29]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1463-5224.2011.00986.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2011.00986.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,29]]},"assertion":[{"value":"2011-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}