{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:45:50Z","timestamp":1762015550582},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold>To describe a case of a cat with primary B\u2010cell lymphoma affecting the eye and brain and which shared features similar to oculo\u2010cerebral lymphoma in humans.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>A 13\u2010year\u2010old castrated male Persian cat presented with clinical signs of anterior uveitis and increased intraocular pressure (IOP) in the left eye (OS). A complete diagnostic work\u2010up was declined, and left\u2010eye enucleation was performed. The globe was submitted for histopathology. One week after surgery, the cat became inappetent, hypothermic, and aggressive. Euthanasia was requested by the owner, and a necropsy was permitted.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Histopathology of the enucleated globe revealed an extensive neoplastic infiltration consistent with large\u2010cell lymphoma, affecting the anterior uvea, neuroretina and optic nerve. At necropsy, all organs were unremarkable except for the brain, where there was a neoplastic cell population consistent with that described in the left eye, infiltrated and expanded meninges, and perivascular spaces. Immunohistochemically, the neoplastic cells were positive for B\u2010cell marker (CD20) and negative for T\u2010cell marker (CD3). Histology and immunophenotyping suggested a diagnosis of primary central nervous system and ocular large B\u2010cell lymphoma.<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold>The lymphoma in this cat resembled oculo\u2010cerebral lymphoma in humans, sharing similar clinical features and histopathological findings, including the perivascular pattern of neoplastic cell infiltration. To the best of the authors\u2019 knowledge, this is the first description of a primary oculo\u2010cerebral B\u2010cell lymphoma in a cat.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2012.01025.x","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T10:14:36Z","timestamp":1335176076000},"page":"77-81","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case of oculo\u2010cerebral B\u2010cell lymphoma in a 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