{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:04:56Z","timestamp":1767625496471,"version":"3.40.3"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T00:00:00Z","timestamp":1343692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold>The purpose of this study was to evaluate the efficacy of an aqueous calcineurin inhibitor, SCY\u2010641, in the treatment of naturally occurring canine immune\u2010mediated keratoconjunctivitis sicca (KCS).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>A randomized, double\u2010masked, placebo\u2010controlled clinical study of 56\u2010day duration was performed in dogs with naturally occurring immune\u2010mediated KCS assigned to treatment with either topical twice\u2010daily aqueous calcineurin inhibitor solution (SCY\u2010641) or artificial tears (placebo) by the study administrator. Clinical examination and Schirmer tear tests (STT) were performed prior to therapy and at days 7, 14, 28, and 56 after initiation of treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Twenty dogs were enrolled in the study with ten receiving placebo and 10 receiving SCY\u2010641 in one or both eyes. No adverse effects were noted with any treatment. There were no significant differences in mean STT values in dogs in group either at day 0 (prior to therapy) or after 7\u2003days of treatment. At 14, 28, and 56\u2003days after initiation of treatment, mean STT and increase in STT over baseline in dogs treated with SCY\u2010641 were significantly higher than in dogs treated with placebo (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.04).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>SCY\u2010641 was well tolerated by dogs with naturally occurring KCS, and by 14\u2003days after initiating therapy, dogs treated with SCY\u2010641 had significantly higher STT than placebo\u2010treated dogs. These preliminary results indicate that topical SCY\u2010641, in a stable clear aqueous solution, is efficacious in a spontaneous model of KCS and warrants further evaluation as a treatment of immune\u2010mediated KCS.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2012.01056.x","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T18:50:30Z","timestamp":1343847030000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs"],"prefix":"10.1111","volume":"16","author":[{"given":"Brian C.","family":"Gilger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacklyn 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