{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:36:01Z","timestamp":1785792961580,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ocular thelaziosis caused by <jats:italic>Thelazia callipaeda<\/jats:italic> is a vector\u2010borne disease affecting dogs and humans. We report a case of thelaziosis in a 10\u2010year\u2010old German Shepherd dog from Vila Real city (Portugal). Ophthalmological examination revealed bulbar and nictitating membrane conjunctival hyperemia with serous discharge noted at the left medial canthus and blepharitis. Schirmer tear test value and intraocular pressure were within the reference ranges in both eyes, and biomicroscopy showed a transparent cornea without lesions or edema and no inflammatory reaction in the anterior chamber. No funduscopic alterations were detected by direct and indirect ophthalmoscopic examination. When testing the nasolacrimal patency, two white worms were observed on the caruncle conjunctival surface with undulating movements that increased with light intensity. In total, eight worms were collected and morphologically identified as <jats:italic>T.\u00a0callipaeda<\/jats:italic> (seven mature females and one male). PCR amplification of a 689 sequence of partial cytochrome <jats:italic>c<\/jats:italic> oxidase subunit 1 target gene confirmed the nematodes were <jats:italic>T.\u00a0callipaeda<\/jats:italic>, haplotype 1. The dog was treated with a single subcutaneous injection of ivermectin combined with additional topical application of ophthalmic fusidic acid drops and oral milbemycin oxime. One week after treatment, no worms were detected and the ocular clinical signs resolved. The most recent reports of canine thelaziosis in the Iberian Peninsula should alert local health authorities to the zoonotic potential of infestation with <jats:italic>T.\u00a0callipaeda<\/jats:italic>, which should be included in the differential diagnosis of conjunctivitis in dogs and humans.<\/jats:p>","DOI":"10.1111\/j.1463-5224.2012.01074.x","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T04:10:18Z","timestamp":1350360618000},"page":"312-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Canine ocular thelaziosis caused by <i>Thelazia callipaeda<\/i> in Portugal"],"prefix":"10.1111","volume":"16","author":[{"given":"Paulo","family":"Pimenta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Maltez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Otranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,15]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-43.3.508"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.08.027"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-4-148"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.07.029"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1404.071205"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2003.07.022"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.10.008"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-4-41"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1612.100872"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.08.005"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.18.568"},{"key":"e_1_2_4_13_2","first-page":"433","article-title":"First case of dacryocystitis due to Thelazia callipaeda in a dog in Belgium. Abstracts: European College of Veterinary Ophthalmologists and European Society of Veterinary Ophthalmology; 2006 May 10\u201314; Brugge, Belgium","volume":"9","author":"Janssens G","year":"2006","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_4_14_2","first-page":"109","article-title":"Hallazgo de infecci\u00f3n por nematodos del g\u00e9nero Thelazia (Boso, 1819) en un perro de Salamanca (Espa\u00f1a)","volume":"70","author":"Dacal V","year":"2011","journal-title":"Revista Ibero-latinoamericana de Parasitolog\u00eda"},{"key":"e_1_2_4_15_2","unstructured":"Su\u00e1rez\u2010Bard\u00f3nR San Jose\u2010V\u00e1squezJ.Descripci\u00f3n de un caso de conjuntivitis porThelazia callipaedaen un gato.Proceedings of the 28th Annual Meeting of AMVAC 2012 Mar 11\u201313; Madrid Spain."},{"key":"e_1_2_4_16_2","unstructured":"RodriguesF CoutinhoT CardosoLet\u00a0al.Caso cl\u00ednico de telaziose felina no distrito de Bragan\u00e7a.Proceedings of the 8th Congress of Hospital Veterin\u00e1rio Montenegro 2012 Feb 11\u201312; Santa Maria da Feira Portugal."},{"key":"e_1_2_4_17_2","first-page":"125","article-title":"Thelazia callipaeda (Spirurida, Thelaziidae) of carnivores and humans: morphological study by light and scanning electron microscopy","volume":"45","author":"Otranto D","year":"2003","journal-title":"Parassitologia"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008395"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-124"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.12.020"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.03.011"},{"key":"e_1_2_4_22_2","first-page":"662","volume-title":"Veterinary Ophthalmology","author":"Hendrix D","year":"2007"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.11.005"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-823R.1"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-011-0050-2"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.10.1194a"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1463-5224.2012.01074.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1463-5224.2012.01074.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:22:30Z","timestamp":1696162950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1463-5224.2012.01074.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,15]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/j.1463-5224.2012.01074.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1463-5224.2012.01074.x","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,15]]},"assertion":[{"value":"2012-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}