{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:23:08Z","timestamp":1774520588930,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T00:00:00Z","timestamp":1144281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To investigate whether a range of cytokines were detectable in the seminal plasma and urine of men with chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) and nonspecific urethritis (NSU), and whether cytokine levels correlated with symptom severity in CP\/CPPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>In all, 87 men participated, 33 with CP\/CPPS, 31 with NSU, and 23 controls. Interleukin (IL)\u20101\u03b2, IL\u20102, IL\u20106, IL\u20108 and IL\u201010 were measured in seminal plasma and first pass urine, and the results were correlated with scores for pain, urinary symptoms and quality\u2010of\u2010life impact using a validated symptom index, the National Institutes of Health Chronic Prostatitis Symptom Index (NIH\u2010CPSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Seminal plasma levels of IL\u20108 were higher in men with CP\/CPPS and NSU than in controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001), and the levels correlated with NIH\u2010CPSI symptom scores in men with CP\/CPPS. There were no significant differences in urinary IL\u20108 levels in the three groups, and no significant differences in levels of the other cytokines in either semen or urine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Semen IL\u20108 levels correlate with subjective symptoms in men with CP\/CPPS. IL\u20108 might contribute to the pathophysiology of CP\/CPPS and NSU, and elevated levels might be a useful marker of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2006.06133.x","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:25:13Z","timestamp":1144326313000},"page":"1043-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Interleukin\u20108 levels in seminal plasma in chronic prostatitis\/chronic pelvic pain syndrome and nonspecific urethritis"],"prefix":"10.1111","volume":"97","author":[{"given":"ABBAS","family":"KHADRA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICIA","family":"FLETCHER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRAZ","family":"LUZZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBIN","family":"SHATTOCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILLIP","family":"HAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00481.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.5.807"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000136002.76898.04"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00205-8"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015904721223"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00390-2"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67497-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000030218"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)69139-0"},{"key":"e_1_2_8_11_2","first-page":"179","article-title":"Evaluation of the cytokines in genital secretions of patients with chronic prostatitis","volume":"75","author":"Paulis G","year":"2003","journal-title":"Arch Ital Urol Androl"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052415"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00844-X"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2001.00358.x"},{"key":"e_1_2_8_15_2","first-page":"S26","article-title":"Biochemical markers for inflammation and glands that contribute to the semen in chronic prostatitis patients (Abstract)","volume":"163","author":"Ruggieri MR","year":"2000","journal-title":"J Urol"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-1-21"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000082252.49374.e9"},{"key":"e_1_2_8_18_2","unstructured":"HornerPJ ShahmaneshM:Clinical Effectiveness Group. National guideline on the management of non\u2010gonococcal urethritis. Available at:http:\/\/www.bashh.org\/guidelines\/2002\/ngu_0901c.pdfAccessedDecember 2005"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68562-X"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.7178-7181.2001"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-410X.2006.06133.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-410X.2006.06133.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:58:32Z","timestamp":1761739112000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-410X.2006.06133.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,6]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1464-410X.2006.06133.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-410x.2006.06133.x","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,6]]},"assertion":[{"value":"2006-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}