{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:30:30Z","timestamp":1775010630029,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T00:00:00Z","timestamp":1144281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To characterize the contractile activity that occurs in the bladder during the filling phase of the micturition cycle (non\u2010micturition contractions, NMCs), which generate transient rises in intravesical pressure not associated with urine flow.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>The experiments were conducted using anaesthetized (chloral hydrate) and un\u2010anaesthetized rats. In un\u2010anaesthetized rats bladder contractile activity was measured using an intravesical cannula implanted under full surgical anaesthesia 3\u2003days previously. In the anaesthetized rats the bladder was exteriorized and a cannula inserted through the dome. In these experiments electrical activity within the detrusor was also measured with a suction electrode on the bladder surface. For each rat, the experimental protocol involved filling the bladder at a constant rate (10\u2003mL\/h) to evoke micturition cycles, or infusion of a fixed volume and recording made under effective isovolumetric conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In both anaesthetized and un\u2010anaesthetized rats there were transient rises in bladder pressure (0.5\u20133\u2003cmH\n                      <jats:sub>2<\/jats:sub>\n                      O). In the anaesthetized rats the amplitude of the transients increased throughout the filling phase, with little change in frequency. The phasic NMCs generating these pressure transients were accompanied by electrical changes in the detrusor. In the middle phase of bladder filling the slow pressure changes were accompanied by slow waves of electrical activity which changed in the pressure cycles immediately before micturition to high\u2010frequency low\u2010amplitude signals. In the un\u2010anaesthetized rats there was a period immediately after voiding where there was no activity. As filling proceeded, low\u2010amplitude low\u2010frequency NMCs appeared that gradually increased in frequency and amplitude during the filling phase. However, the frequency of the transients decreased immediately before micturition despite an increase in amplitude. Similar responses were seen during isovolumetric recording.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The present results show the presence of NMCs in the rat bladder, identify volume\u2010dependent changes in the pattern of this activity during the micturition cycle, and show that NMCs are accompanied by electrical changes in the detrusor. The physiological significance of NMCs is not known but it might be linked to the generation of afferent discharge from mechanoreceptors in the wall, so contributing to sensations related to bladder volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2006.06137.x","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:25:13Z","timestamp":1144326313000},"page":"1094-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Phasic non\u2010micturition contractions in the bladder of the anaesthetized and awake rat"],"prefix":"10.1111","volume":"97","author":[{"given":"TOMI","family":"STRENG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETTER","family":"HEDLUND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTTI","family":"TALO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARL\u2010ERIK","family":"ANDERSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES I.","family":"GILLESPIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1892.sp000428"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1955.sp005327"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1965.tb04287.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365598009179565"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.5.1842"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)80012-W"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04667.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05652.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802536"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802473"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04624.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04727.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05113.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04626.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05268.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04840.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930120504"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.251.2.R250"},{"key":"e_1_2_7_20_2","first-page":"R98","article-title":"A comparative study of voiding in the rat and guinea pig: simultaneous measurement of flow rate and pressure","volume":"269","author":"Van Asselt E","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2001)20:2<197::AID-NAU22>3.0.CO;2-F"},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/ajplegacy.1959.196.6.1297","article-title":"Comparison of cardiac monophasic action potentials recorded by intracellular and suction electrodes","volume":"196","author":"Hoffman BF","year":"1959","journal-title":"Am J Physiol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36339-5"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1993.tb09550.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.1.R238"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000069722.35137.e0"},{"key":"e_1_2_7_27_2","first-page":"291","article-title":"Sur le fonctions de la vessie","volume":"1","author":"Mosso MA","year":"1882","journal-title":"Arch Ital Biol"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/56.2.149"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.03840110011002"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.08981.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09769.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05455.x"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-410X.2006.06137.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-410X.2006.06137.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:58:38Z","timestamp":1761739118000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-410X.2006.06137.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,6]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1464-410X.2006.06137.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-410x.2006.06137.x","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,6]]},"assertion":[{"value":"2006-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}