{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:29:11Z","timestamp":1794443351375,"version":"4.9.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T00:00:00Z","timestamp":1154476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>\n                      To explore the effect of the vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      analogue, BXL\u2010628, on some of the consequences of bladder outlet obstruction (BOO), e.g. hypertrophy and loss of contractile function, as vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      and BXL\u2010628 inhibit prostate and bladder cell growth\n                      <jats:italic>in vitro<\/jats:italic>\n                      , and there are receptors for vitamin D in rat and human bladder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIAL AND METHODS<\/jats:title>\n                    <jats:p>\n                      In female rats, BOO was produced by a standardized method; one group received daily BXL\u2010628 (150\u2003\u00b5g\/kg per day) and the remaining rats received vehicle. Sham\u2010operated rats received BXL\u2010628 or vehicle. After 2\u2003weeks, the conscious rats were assessed by cystometry. Plasma calcium levels were determined and\n                      <jats:italic>in vitro<\/jats:italic>\n                      contractility assessed at the end of the experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      There was a significant increase in bladder weight, micturition interval and volume, and in bladder capacity in both the obstructed groups compared to sham controls, but no difference between the obstructed groups. On plotting the micturition pressure against bladder weight within the obstructed groups, there was a clear correlation in the vehicle\u2010treated group, indicating a decrease in contractile function with increasing bladder weight. There was no such correlation in the treatment group.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , there was a strong correlation of increasing bladder weights vs decrease in response to KCl and electrical\u2010field stimulation in strips from obstructed vehicle\u2010treated rats, but no correlation in those from drug\u2010treated rats. Treatment increased the plasma calcium level by 12%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      analogue used did not prevent bladder hypertrophy, but appeared to reduce some of the negative functional changes of the bladder smooth muscle, which occurs with BOO\u2010induced increases in bladder weight.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2006.06342.x","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T16:19:08Z","timestamp":1154535548000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effects of a vitamin D\n                    <sub>3<\/sub>\n                    analogue in a rat model of bladder outlet obstruction"],"prefix":"10.1111","volume":"98","author":[{"given":"ANNETTE","family":"SCHR\u00d6DER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ENRICO","family":"COLLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIO","family":"MAGGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARL\u2010ERIK","family":"ANDERSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000280347"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1992.tb15791.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(02)00119-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2003"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.09.030"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2576"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1496"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000133561.32285.23"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000070926.39442.4c"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68236-5"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750042114"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200101000-00072"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008880410015336"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40176-5"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32614-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)69006-4"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500591"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-410X.2006.06342.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-410X.2006.06342.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:30:54Z","timestamp":1761755454000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-410X.2006.06342.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,2]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1464-410X.2006.06342.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-410x.2006.06342.x","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,2]]},"assertion":[{"value":"2006-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}