{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:17:55Z","timestamp":1791271075903,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,5]],"date-time":"2008-09-05T00:00:00Z","timestamp":1220572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report a multicentre, community based open\u2010label study designed to assess the efficacy and safety of intravesical sodium chondroitin sulphate in the treatment of patients with the clinical diagnosis of interstitial cystitis (IC). Chondroitin sulphate is a naturally occurring glycosaminoglycan (GAG) in the bladder mucus layer and changes in this GAG have been implicated in the pathogenesis of IC, and small single\u2010centre studies have suggested that intravesical chondroitin sulphate may have efficacy in IC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>Patients with IC were treated with sodium chondroitin sulphate (Uracyst\u00ae, Stellar Pharmaceuticals Inc., London ON, Canada) solution 2.0% via urinary catheter weekly for 6\u2003weeks and then monthly for 16\u2003weeks for a total of 10 treatments. The primary efficacy endpoint was the percentage of responders to treatment as indicated by a marked or moderate improvement on a seven\u2010point patient Global Response Assessment (GRA) scale at week 10 (4\u2003weeks after the initial six treatments) compared with baseline. A major secondary efficacy endpoint (durability) was the percentage of responders on the GRA scale after 10 treatments. Additional secondary efficacy objectives were differences from baseline in Patient Symptom\/Problem Index scores over the course of the treatment compared with baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In all, 47% of the 53 enrolled patients with long standing moderately severe IC (mean [\n                      <jats:sc>sd<\/jats:sc>\n                      , range] diagnosis of IC 3.0\u2003[3.4, 0.1\u201316]\u2003years; duration of symptoms 9.2\u2003[9.2, 1\u201339]\u2003years; baseline symptom score 14.2\u2003[3.2]) were responders at week 10. At 24\u2003weeks, 60% were responders. There was a statistically and clinically significant decrease in the mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) symptom and bother scores from baseline at 10\u2003weeks and 24\u2003weeks, at 9.0\u2003(4.3) and 8.1\u2003(5.0), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001). There were no significant safety issues during the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This multicentre community based real\u2010life clinical practice study suggests that intravesical chondroitin sulphate may have an important role in the treatment of IC and validates the rationale for a randomized placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2008.08028.x","type":"journal-article","created":{"date-parts":[[2008,9,5]],"date-time":"2008-09-05T13:03:16Z","timestamp":1220619796000},"page":"56-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A real\u2010life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis"],"prefix":"10.1111","volume":"103","author":[{"given":"J. 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