{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:46:27Z","timestamp":1792395987126,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T00:00:00Z","timestamp":1221177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the reliability and validity of the Premature Ejaculation Profile (PEP), a self\u2010reported outcome instrument for evaluating domains of PE and its treatment, comprised of four single\u2010item measures, a profile, and an index score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUBJECTS AND METHODS<\/jats:title>\n                    <jats:p>Data were from men participating in observational studies in the USA (PE, 207 men; non\u2010PE, 1380) and Europe (PE, 201; non\u2010PE, 914) and from men with PE (1238) participating in a phase III randomized, placebo\u2010controlled clinical trial of dapoxetine. The PEP contains four measures: perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse, and interpersonal difficulty related to ejaculation, each assessed on five\u2010point response scales. Test\u2010retest reliability, known\u2010groups validity, and ability to detect a patient\u2010reported global impression of change (PGI) in condition were evaluated for the individual PEP measures and a PEP index score (the mean of all four measures). Profile analysis was conducted using multivariate analysis of variance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      All PEP measures showed acceptable reliability (intraclass correlation coefficients ranged from 0.66 to 0.83) and mean scores for all measures differed significantly between PE and non\u2010PE groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001). Men who reported a reduction in PE with treatment in the phase III trial had significantly greater scores on each of the four measures. The PEP profiles of men with and without PE differed significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001) in both observational studies; higher levels of PGI were associated with higher PEP profiles (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001). The PEP index score also showed acceptable reliability and was significantly different between the PE and non\u2010PE groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2003&lt;\u20030.001). Men who reported an improvement in PE with treatment in the phase III trial had significantly greater PEP index scores. In the phase III trial, nausea was the most common adverse event with dapoxetine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The PEP provides a reliable, valid, and interpretable measure for use in monitoring outcomes of men with PE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2008.08041.x","type":"journal-article","created":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T12:31:57Z","timestamp":1221222717000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["The Premature Ejaculation Profile: validation of self\u2010reported outcome measures for research and practice"],"prefix":"10.1111","volume":"103","author":[{"given":"Donald L.","family":"Patrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Fai","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20353.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10109.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00275.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10104.x"},{"key":"e_1_2_8_7_2","first-page":"693\u201370","article-title":"Changing paradigms from a historical DSM\u2010III and DSM\u2010IV view toward an evidence\u2010based definition of premature ejaculation. 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