{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:42Z","timestamp":1788955662762,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T00:00:00Z","timestamp":1224201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess whether incomplete bladder emptying and the need for clean intermittent self\u2010catheterization (CISC) is predictable, by analysing urodynamic and detrusor contractility variables in patients treated with botulinum toxin\u2010A (BTX\u2010A) for refractory idiopathic detrusor overactivity (IDO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>Sixty\u2010seven patients (mean age 50.3) with IDO, from two centres, had bladder injections of 200\u2003U BTX\u2010A. Patients with difficulty in emptying their bladder and\/or persistent overactive bladder symptoms, with postvoid residual volumes (PVR) of &gt;150\u2003mL after treatment were started on CISC. Urodynamics were conducted at baseline, 4 and 12\u201316\u2003weeks after injection with BTX\u2010A. Detrusor contractility was assessed using the projected isovolumetric pressure (PIP1) in women and bladder contractility index (BCI) in men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      There were improvements in the mean maximum cystometric capacity, bladder compliance and maximum detrusor pressures during filling cystometry after BTX\u2010A injections. The PVR was significantly increased at 4 but not at 12\u2003weeks. Nineteen patients required CISC and when compared with those not needing CISC their pretreatment maximum flow rate (15 vs 22\u2003mL\/s,\n                      <jats:italic>P<\/jats:italic>\n                      \u2003=\u20030.003), PIP1 (43 vs 58,\n                      <jats:italic>P<\/jats:italic>\n                      \u2003=\u20030.02) and BCI (113 vs 180,\n                      <jats:italic>P<\/jats:italic>\n                      \u2003=\u20030.001) were lower. Receiver operator characteristic curve analysis suggested that a PIP1 of \u226450 in women (sensitivity 0.83; specificity 0.70; area under the curve 0.822) and BCI \u2264120 (sensitivity 0.7; specificity 0.79; area 0.879) might predict the need for CISC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The maximum flow rate, PIP1 and BCI were significantly lower in patients who required CISC after BTX\u2010A treatment than in those who did not. A PIP1 of \u226450 in women and a BCI of \u2264120 might be predictive of a need for CISC in this setting, and might help when counselling patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-410x.2008.08076.x","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T10:43:11Z","timestamp":1232448191000},"page":"630-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Assessment of urodynamic and detrusor contractility variables in patients with overactive bladder syndrome treated with botulinum toxin\u2010A: is incomplete bladder emptying predictable?"],"prefix":"10.1111","volume":"103","author":[{"given":"Arun","family":"Sahai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Sangster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Kalsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad S.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare J.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prokar","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590601068835"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.01.130"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000162035.73977.1c"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.028"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20105"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008880410015426"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182666"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20020"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04312.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06063.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.012"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21209"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000169480.43557.31"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.039"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.05.054"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.136"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2005.19.880"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05725.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01648.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.010"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-410X.2008.08076.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-410X.2008.08076.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T08:38:15Z","timestamp":1761727095000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-410X.2008.08076.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,16]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1111\/j.1464-410X.2008.08076.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-410x.2008.08076.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1137936.595038","asserted-by":"object"}]},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,16]]},"assertion":[{"value":"2009-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}