{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:25:03Z","timestamp":1790223903319,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,3,5]],"date-time":"2004-03-05T00:00:00Z","timestamp":1078444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003\u2002<\/jats:bold> To evaluate the use of a new cell\u2010tailored carrier surface (TranCell) for delivery of autologous keratinocytes to promote wound healing in patients with chronic neuropathic foot ulcers.<\/jats:p><jats:p><jats:bold>Methods\u2003\u2002<\/jats:bold> TranCell is a sterile medical grade polymer coated with a plasma\u2010polymerized functional surface containing 20% carboxylic acid which enables keratinocytes to attach and proliferate. Six diabetic patients with neuropathic ulcers resistant to conventional therapy were treated with weekly applications of autologous keratinocytes delivered on TranCell. A split\u2010thickness skin biopsy was taken from each patient followed by isolation, expansion and freezing down of keratinocytes. Keratinocytes were thawed and seeded on TranCell 48\u00a0h prior to application. This procedure was repeated weekly in addition to conventional therapy until wound healing was achieved.<\/jats:p><jats:p><jats:bold>Results\u2003\u2002<\/jats:bold> Complete healing was achieved in six out of nine ulcers in six patients, a reduction in ulcer size was achieved in one ulcer and no response was seen in one ulcer. Treatment was discontinued in one patient due to development of Methicillin\u2010Resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) after only three applications of TranCell. Wound healing took 6\u201317 applications over 6\u201320\u00a0weeks. There were no recurrences in the healed ulcers after a follow\u2010up of 6\u00a0months.<\/jats:p><jats:p><jats:bold>Conclusions\u2003\u2002<\/jats:bold> TranCell delivery of autologous cells is a promising treatment for chronic diabetic foot ulcers with no side\u2010effects and no recurrence in the healed ulcers.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2004.01166.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T12:33:40Z","timestamp":1100522020000},"page":"786-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["A new autologous keratinocyte dressing treatment for non\u2010healing diabetic neuropathic foot ulcers"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Moustafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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