{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:29:14Z","timestamp":1784716154137,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T00:00:00Z","timestamp":1080259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2003<\/jats:bold> The association of diabetes mellitus with primary open\u2010angle glaucoma has been controversial. The study aimed to examine the strength of this association through a detailed meta\u2010analysis of studies published in peer\u2010reviewed journals.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A comprehensive search for articles published through 2002 was performed and data were abstracted. Prior to meta\u2010analysis, all studies were evaluated for publication bias and heterogeneity. Pooled odds ratio (OR) was calculated using the random and the fixed\u2010effects model.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Twelve studies published between 1987 and 2001 were included (five case\u2013control studies and seven cross\u2010sectional studies). Significant heterogeneity among the studies was detected (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). No evidence of publication bias was found (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.37). The association of diabetes mellitus with primary open\u2010angle glaucoma was statistically significant assuming either a random effects [OR\u00a0= 1.50, 95% confidence interval (CI) 1.16, 1.93], or a fixed\u2010effects model (OR\u00a0= 1.27, 95% CI 1.10, 1.45).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Our meta\u2010analysis results suggest that diabetic patients are at significantly increased risk of developing primary open\u2010angle glaucoma. Clinicians should be aware of this possibility.<\/jats:p><jats:p>Diabet. Med. 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