{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:20:58Z","timestamp":1776147658730,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T00:00:00Z","timestamp":1086566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> Was metformin during pregnancy in women with polycystic ovary syndrome (PCOS) associated with pre\u2010eclampsia, and was it safe for mother and neonate?<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> In the current study, pre\u2010eclampsia and other pregnancy outcomes were prospectively studied in 90 women with PCOS who conceived on metformin 1.5\u20132.55\u00a0g\/day, and had \u2265\u00a01 live birth (97 pregnancies, 100 live births) compared with 252 healthy women (not known to have PCOS) with \u2265\u00a01 live birth, consecutively delivered in a community obstetrics practice.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Women with PCOS were older than controls (33\u00a0\u00b1\u00a05 vs. 29\u00a0\u00b1\u00a06\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), more likely to be &gt;\u00a035\u00a0years old at conception (23 vs. 13%, <jats:italic>P<\/jats:italic>\u00a0= 0.028), much heavier (93\u00a0\u00b1\u00a023 vs. 72\u00a0\u00b1\u00a018\u00a0kg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, BMI 33.8\u00a0\u00b1\u00a07.8\u00a0kg\/m<jats:sup>2<\/jats:sup> vs. 25.6\u00a0\u00b1\u00a05.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and more likely to be Caucasian (97 vs. 90%, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.05), but there were similar numbers with preconception Type\u00a02 diabetes mellitus [2\/90 (2.2%) vs. 1\/252 (0.4%), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.17]. Pre\u2010eclampsia in PCOS (5\/97 pregnancies, 5.2%), did not differ (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.5) from controls (9\/252, 3.6%), nor did it differ (<jats:italic>P\u00a0=<\/jats:italic> 1.0) in PCOS vs. control primigravidas [2\/45 (4.4%) vs. 4\/91 (4.4%)]. Development of gestational diabetes in PCOS did not differ from controls [9\/95 pregnancies (9.5%) vs. 40\/251 (15.9%), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.12]. Of the 100 live births to 90 women with PCOS, there were no major birth defects. Mean\u00a0\u00b1\u00a0<jats:sc>sd<\/jats:sc> birth weight of the 80 live births \u2265\u00a037\u00a0weeks gestation in women with PCOS (3414\u00a0\u00b1\u00a0486\u00a0g) did not differ from controls\u2019 206 live births \u2265\u00a037\u00a0weeks (3481\u00a0\u00b1\u00a0555\u00a0g), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.34, nor did the percentage of \u2265\u00a037\u00a0week gestation neonates \u2265\u00a04000\u00a0g (12.5 vs. 17.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.3) or\u00a0\u2265\u00a04500\u00a0g (1.3 vs. 2.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.7).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Metformin is not associated with pre\u2010eclampsia in pregnancy in women with PCOS, and appears to be safe for mother and fetus.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2004.01251.x","type":"journal-article","created":{"date-parts":[[2004,7,20]],"date-time":"2004-07-20T14:20:46Z","timestamp":1090333246000},"page":"829-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Metformin, pre\u2010eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"C. 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