{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:46:44Z","timestamp":1745819204187},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T00:00:00Z","timestamp":1092787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To compare major determinants of myocardial oxygen demand (heart rate, blood pressure and rate pressure product) in patients with and without diabetes admitted with acute coronary syndromes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A cross\u2010sectional study of the relation between diabetes and haemodynamic indices of myocardial oxygen demand in 2542 patients with acute coronary syndromes, of whom 1041 (41.0%) had acute myocardial infarction and 1501 (59.0%) unstable angina.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Of the 2542 patients, 701 (27.6%) had diabetes. Major haemodynamic determinants of myocardial oxygen demand were higher in patients with than without diabetes: heart rate 80.0\u00a0\u00b1\u00a020.4 vs. 75.2\u00a0\u00b1\u00a019.2 beats\/minute (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001); systolic blood pressure 147.3\u00a0\u00b1\u00a030.3 vs. 143.2\u00a0\u00b1\u00a028.5\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002); rate\u2010pressure product 11533\u00a0\u00b1\u00a04198 vs. 10541\u00a0\u00b1\u00a03689 beats\/minute\u00a0\u00d7\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Multiple regression analysis confirmed diabetes as a significant determinant of presenting heart rate [multiplicative coefficient (MC) 1.05; 95% confidence interval (CI) 1.03\u20131.07; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001], rate pressure product (MC 1.09; CI 1.05\u20131.12; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and systolic blood pressure, which was estimated to be 3.9\u00a0mmHg higher than in patients without diabetes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). These effects of diabetes were independent of a range of baseline variables including acute left ventricular failure and mode of presentation (unstable angina or myocardial infarction).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> In acute coronary syndromes, heart rarte and other determinants of myocardial oxygen demand are higher in patients with than without diabetes, providing a potential contributory mechanism of exaggerated regional ischaemia in this high\u2010risk group.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2004.01413.x","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T13:39:38Z","timestamp":1092836378000},"page":"1025-1031","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of diabetes on heart rate and other determinants of myocardial oxygen demand in acute coronary syndromes"],"prefix":"10.1111","volume":"21","author":[{"given":"K.","family":"Foo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sekhri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Deaner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ranjadayalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Suliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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