{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:51:34Z","timestamp":1771051894881,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T00:00:00Z","timestamp":1108512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Hepatitis\u00a0C virus (HCV) has been associated with Type\u00a02 diabetes mellitus, and many other viral infections have been associated with Type\u00a01 diabetes mellitus (Type\u00a01 DM). An association between HCV and Type\u00a01 DM, however, has never been reported. We report the case of a 66\u2010year\u2010old man who developed Type\u00a01 DM 1\u00a0year after a blood transfusion\u2010related HCV infection. Testing of serum specimens obtained in the weeks following blood transfusion demonstrated evidence of both acute HCV infection and development of Type\u00a01 DM\u2010related autoantibodies.<\/jats:p><jats:p><jats:bold>Case report\u2003<\/jats:bold> A 66\u2010year\u2010old Taiwanese male received blood transfusions during coronary artery bypass surgery in 1987. Serum specimens, obtained as part of a study on post\u2010transfusion hepatitis, demonstrated that the patient had no evidence of hepatitis\u00a0C prior to transfusion, but developed acute HCV infection after transfusion. One year later, the patient, who had no personal or family history of diabetes, presented with diabetic ketoacidosis, and tests for C\u2010peptide confirmed that he had Type\u00a01 DM. Testing of pre\u2010 and post\u2010operative serum specimens demonstrated that the patient developed positive tests for islet cell and glutamic acid decarboxylase antibodies 4\u00a0weeks after transfusion, concurrent with the development of acute HCV infection.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> The simultaneous development of HCV infection and diabetes\u2010related autoantibodies suggest a relationship between HCV and Type\u00a01 DM.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01412.x","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T11:26:16Z","timestamp":1108553176000},"page":"340-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hepatitis\u00a0C virus infection\u2010related Type\u00a01 diabetes 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