{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:00:26Z","timestamp":1783040426380,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T00:00:00Z","timestamp":1113782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To determine the lifetime risk of developing symptomatic carpal tunnel syndrome (CTS) in subjects with Type 1 diabetes and to investigate the effect of glycaemic control, body mass index (BMI), gender and age of onset of diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> One hundred and twenty\u2010two consecutive subjects with Type 1 diabetes seen by a single investigator, over 1\u2010year, were questioned about previous surgery for, or current symptoms of CTS. Those with current symptoms were referred for nerve conduction studies (NCS). Those with previous surgery and\/or diagnostic NCS were classified as having CTS. Lifetime risk was calculated by the Kaplan\u2013Meier method.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Twenty six out of 122 patients had CTS, 18 of whom (69%) had undergone median nerve decompression surgery. The predicted lifetime risk of CTS reached 85% after 54\u00a0years of Type 1 diabetes (95% confidence interval: 72\u201397%). The duration of diabetes was greater in those who had developed CTS than in those who had not (29 vs. 19\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). In those diagnosed with diabetes before the age of 20 there was a lag time of at least 19\u00a0years before the development of CTS, whereas patients with later onset of diabetes, began to develop CTS from as early as 5\u00a0years diabetes duration. There was no demonstrable effect of glycaemic control, obesity, gender or retinopathy on the appearance of CTS.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> The lifetime risk of developing symptomatic CTS with Type 1 diabetes is high, and is related to age and duration of diabetes, but not to the development of microvascular complications.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01487.x","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T08:45:18Z","timestamp":1113813918000},"page":"625-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Lifetime risk of symptomatic carpal tunnel syndrome in Type 1 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