{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:02:54Z","timestamp":1761894174943},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2003<\/jats:bold> To evaluate the effect of sibutramine on weight loss, insulin sensitivity and serum adiponectin levels in obese patients with Type 2 diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> This study is a randomized, double\u2010blind, placebo\u2010controlled parallel comparison study of sibutramine 15\u00a0mg\/day and placebo. Forty\u2010eight eligible obese patients with Type 2 diabetes (age between 30 and 75\u00a0years with body mass index \u2265\u00a027\u00a0kg\/m<jats:sup>2<\/jats:sup>) were randomly assigned to receive either placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) or sibutramine (15\u00a0mg\/day) (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) for 6\u00a0months. Fifteen subjects in each group underwent meal tests and modified insulin suppression tests before and after 6\u00a0months\u2019 treatment.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> After 6\u00a0months of sibutramine treatment statistically significant changes from baseline were observed for body weight (85.4\u00a0\u00b1\u00a02.5 vs. 82.9\u00a0\u00b1\u00a02.4\u00a0kg, <jats:italic>P<\/jats:italic>\u00a0&lt; 0.005) and body mass index (32.0\u00a0\u00b1\u00a00.7 vs. 31.4\u00a0\u00b1\u00a00.6\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) without a significant alteration of waist\u2013hip ratio (W\/H), blood pressure, heart rate, glycaemic parameters or lipid profiles. The steady\u2010state plasma glucose (SSPG) level during the modified insulin suppression test was significantly reduced in the sibutramine group (17.33\u00a0\u00b1\u00a02.92 vs. 14.29\u00a0\u00b1\u00a04.19\u00a0mmol\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) despite similar steady\u2010state plasma insulin (SSPI) concentrations. In addition, serum adiponectin and C\u2010reactive protein (CRP) levels remained unchanged, although modest weight reduction was achieved after sibutramine treatment. There were also no significant correlations between changes in serum adiponectin and reduction of SSPG or body weight. Daily ambient plasma insulin and glucose concentrations in response to a test meal were not significantly different in subjects receiving sibutramine treatment.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> We conclude that treatment with sibutramine 15\u00a0mg once daily effectively reduces weight and enhances insulin sensitivity without alteration of serum adiponectin levels in obese patients with Type 2 diabetes.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01569.x","type":"journal-article","created":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T10:46:02Z","timestamp":1126521962000},"page":"1024-1030","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sibutramine improves insulin sensitivity without alteration of serum adiponectin in obese subjects with Type 2 diabetes"],"prefix":"10.1111","volume":"22","author":[{"given":"Y.\u2010J.","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010W.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010H.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010T.","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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