{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:46:47Z","timestamp":1793764007987,"version":"4.6.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T00:00:00Z","timestamp":1124064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To examine the association of non\u2010alcoholic hepatic steatosis (HS) with the activity of the hypothalamo\u2010pituitary\u2010adrenal (HPA) axis in Type\u00a02 diabetic individuals.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> The activity of the HPA axis, as measured by 24\u2010h urinary free cortisol (UFC) excretion and serum cortisol levels after 1.0\u00a0mg dexamethasone, was measured in 40 diet\u2010controlled, predominantly overweight, Type\u00a02 diabetic patients with non\u2010alcoholic HS and in 40 diabetic patients without HS who were comparable for age, sex and body mass index (BMI).<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Subjects with non\u2010alcoholic HS had significantly higher 24\u2010h UFC excretion (191\u00a0\u00b1 4 vs. 102\u00a0\u00b1\u00a03\u00a0nmol\/24\u00a0h; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and post\u2010dexamethasone cortisol concentrations (29.1\u00a0\u00b1 2 vs. 14.4\u00a0\u00b1\u00a01\u00a0nmol\/l; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than those without HS. Patients with HS had significantly higher values for HOMA insulin resistance score, plasma triglycerides and liver enzymes. Age, sex, BMI, waist\u2013hip ratio (WHR), diabetes duration, HbA<jats:sub>1c<\/jats:sub>, LDL\u2010cholesterol and blood pressure values were not different between the groups. The differences in urinary and serum cortisol concentrations between the groups remained significant after adjustment for age, sex, BMI, WHR, HOMA insulin resistance score, plasma triglycerides, HbA<jats:sub>1c<\/jats:sub> and liver enzymes. In multiple logistic regression analyses, 24\u2010h UFC or serum cortisol concentrations (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02, respectively), along with age and HOMA insulin resistance, predicted the presence of HS, independently of potential confounders.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> These results demonstrate that non\u2010alcoholic HS is closely associated with a subtle, chronic overactivity of the HPA axis in diet\u2010controlled Type\u00a02 diabetic individuals.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01583.x","type":"journal-article","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T07:59:33Z","timestamp":1124092773000},"page":"1146-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Relationship of non\u2010alcoholic hepatic steatosis to cortisol secretion in diet\u2010controlled Type\u00a02 diabetic patients"],"prefix":"10.1111","volume":"22","author":[{"given":"G.","family":"Targher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zoppini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zenari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Falezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.2057"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)11222-8"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1284-4"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1126\/science.1066285","article-title":"A transgenic model of visceral obesity and the metabolic syndrome","volume":"7","author":"Masuzaki H","year":"2001","journal-title":"Science"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103676200"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0038-1650524","article-title":"Liver steatosis and its relation to plasma haemostatic factors in apparently healthy males. 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