{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:25:58Z","timestamp":1790324758138,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:00:00Z","timestamp":1119916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2003<\/jats:bold>\n                    At the onset of acute diabetic Charcot foot, therapeutic intervention may be delayed because plain X\u2010rays may not show fractures.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim of the study\u2003<\/jats:bold>\n                    To assess the clinical course of acute Charcot foot in 24 patients without evidence of definite fractures on the first X\u2010ray after onset of symptoms, who were referred to the foot clinic for diagnosis and treatment either early or delayed, i.e. before or after definite fractures were detectable on repeat X\u2010rays.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods\u2003<\/jats:bold>\n                    Eleven patients were referred early (incipient Charcot foot, case group), and 13 patients were referred delayed (overt Charcot foot, control group). In the foot clinic, both groups were immediately treated with off\u2010loading and total contact casting. After the healing process of the Charcot foot was complete, the extent of fractures and subsequent deformities were evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2003<\/jats:bold>\n                    Based on X\u2010rays at the onset of symptoms, in 19 of the 24 patients the condition had been misdiagnosed prior to referral (in 11 patients as sprain injury). Additional imaging techniques (MRI, CT scan or bone scintigraphy) had been performed in 10 patients prior to referral. While these techniques had been used more frequently in the cases vs. the controls (\n                    <jats:italic>P\u00a0=<\/jats:italic>\n                    \u00a00.012), misdiagnosis was less frequent in the cases vs. the controls (\n                    <jats:italic>P\u00a0=<\/jats:italic>\n                    \u00a00.013). Only one out of 11 case patients developed extended foot fractures and severe deformity, vs. 12 out of 13 control patients (\n                    <jats:italic>P\u00a0&lt;<\/jats:italic>\n                    \u00a00.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2003<\/jats:bold>\n                    Early detection of incipient Charcot foot is facilitated by imaging techniques other than plain X\u2010rays. Immediate off\u2010loading of incipient Charcot foot appears to minimize fractures and incapacitating deformities.\n                  <\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01677.x","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T07:44:01Z","timestamp":1124955841000},"page":"1707-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["The perils of procrastination: effects of early vs. delayed detection and treatment of incipient Charcot fracture"],"prefix":"10.1111","volume":"22","author":[{"given":"E.","family":"Chantelau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-4-210"},{"key":"e_1_2_8_3_2","volume-title":"Charcot Joints.","author":"Eichenholtz SN.","year":"1966"},{"key":"e_1_2_8_4_2","first-page":"144A","article-title":"The charcot joint: understanding its natural history leads to new treatment and prevention","volume":"1","author":"Edmonds ME","year":"1984","journal-title":"Abstract Diabetic Med"},{"key":"e_1_2_8_5_2","first-page":"A277","article-title":"Early diagnosis of Charcot osteoarthropathy: the opportunity to arrest its development","volume":"44","author":"Petrova N","year":"2001","journal-title":"Diabetologia"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1990.tb01319.x"},{"key":"e_1_2_8_7_2","volume-title":"Series in Radiology","author":"Forgacs S.","year":"1982"},{"key":"e_1_2_8_8_2","unstructured":"OnvleeGJ.The Charcot foot. A critical review and an observational study of a group of 60 patients.Thesis.The Netherlands: University of Leiden 1998."},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199907001-00002"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002560000316"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679708999030"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002640100253"},{"key":"e_1_2_8_13_2","first-page":"A32","article-title":"Markers for Charcot's neurogenic osteo\u2010arthropathy in diabetic patients","volume":"49","author":"Piaggesi A","year":"2000","journal-title":"Diabetes"},{"key":"e_1_2_8_14_2","first-page":"A40","article-title":"Is there a pre\u2010existing osteopenia that predisposes to Charcot osteoarthropathy or does osteopenia only develop after onset?","volume":"53","author":"Petrova NL","year":"2004","journal-title":"Diabetes"},{"key":"e_1_2_8_15_2","first-page":"A144","article-title":"Evaluation of serum markers of bone turnover and osteopenic risk factors in Type\u20102 diabetics with and without peripheral neuropathy","volume":"48","author":"Subramanian V","year":"1999","journal-title":"Diabetes"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930.61.7.459"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930.61.7.451"},{"key":"e_1_2_8_18_2","volume-title":"Basic Pathology","author":"Kumar V","year":"1997"},{"key":"e_1_2_8_19_2","first-page":"67","article-title":"Fractures and luxations of the mid\u2010 and forefoot (in German)","volume":"20","author":"Brutscher R.","year":"1991","journal-title":"Orthop\u00e4de"},{"key":"e_1_2_8_20_2","first-page":"387","article-title":"Salvage of the diabetic foot\u2014an interdisciplinary challenge (in German)","volume":"121","author":"Jung V.","year":"1996","journal-title":"Zentralbl Chir"},{"key":"e_1_2_8_21_2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1177\/107110070002101105","article-title":"Current practice patterns in the treatment of Charcot foot","volume":"21","author":"Pinzur MS","year":"2000","journal-title":"Foot Ankle Int"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.30.S58.3"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470846399.ch17"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2005.01677.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2005.01677.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:22:17Z","timestamp":1696926137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2005.01677.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,28]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1464-5491.2005.01677.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2005.01677.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,28]]},"assertion":[{"value":"2005-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}