{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:25:08Z","timestamp":1697001908809},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T00:00:00Z","timestamp":1127779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Low\u2010carbohydrate diets are popular and fashionable for weight loss despite lack of evidence about long\u2010term effects. Many individuals attempting to lose weight have hypertension, especially those with diabetes, and the prevalence of hyperaldosteronism among hypertensive patients is higher than previously recognized. We present a patient with Type 2 diabetes and previously undiagnosed hyperaldosteronism who developed life\u2010threatening hypokalaemia while following a low\u2010carbohydrate diet.<\/jats:p><jats:p><jats:bold>Case Report\u2003<\/jats:bold> A 60\u2010year\u2010old man with diet\u2010treated Type 2 diabetes and hypertension presented with generalized muscle weakness and serum potassium of 1.9\u00a0mmol\/l. He had succeeded in losing three and a half stones during the previous 4 months by adhering strictly to a low\u2010carbohydrate diet. HbA<jats:sub>1c<\/jats:sub> was 4.8% and plasma aldosterone:renin ratios were elevated suggestive of increased aldosterone secretion. On a low\u2010calorie mixed diet serum potassium levels were maintained in the low\u2010normal range over the following 165 days. The adrenals were normal on CT scanning and blood pressure responded dramatically to the addition of spironolactone on day 212 (125\/83\u00a0mmHg).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> The prevalence of primary hyperaldosteronism in the hypertensive population, based on elevation of plasma renin:aldosterone ratio, is approximately 6%. The majority of these people are normokalaemic and remain undiagnosed. However, when carbohydrate intake is restricted such individuals are at increased risk of potentially life\u2010threatening metabolic derangements.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01714.x","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T08:18:57Z","timestamp":1127809137000},"page":"1605-1607","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Life\u2010threatening hypokalaemia on a low\u2010carbohydrate diet associated with previously undiagnosed primary hypoaldosteronism"],"prefix":"10.1111","volume":"22","author":[{"given":"A.","family":"Advani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000079505.25750.11"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000176515"},{"key":"e_1_2_6_4_2","volume-title":"Letter on Corpulence, Addressed to the Public","author":"Banting W","year":"1863"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022207"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022637"},{"key":"e_1_2_6_7_2","first-page":"409","volume-title":"Clinical Nutrition and Dietetics","author":"Zeman FJ","year":"1991"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.148.4.873"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(03)00030-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200295090-00018"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001554"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2005.01714.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2005.01714.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:11:04Z","timestamp":1696939864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2005.01714.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,19]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1111\/j.1464-5491.2005.01714.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2005.01714.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,19]]},"assertion":[{"value":"2005-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}