{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:55:19Z","timestamp":1770749719186,"version":"3.50.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T00:00:00Z","timestamp":1121990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To explore the contribution of islet autoimmunity and genetic mutations in Chinese patients initially thought to have Type\u00a01B diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A group of 33 Chinese patients with newly diagnosed Type\u00a01B diabetes, were identified by the absence of autoantibodies to glutamic acid decarboxylase (GAD), IA\u20102, insulin, thyroid globulin or thyroid peroxidase, or high\u2010risk HLA\u2010DQ haplotypes. The cohort was further characterized by measurement of autoantibodies to carboxypeptidase\u00a0H (CPH) and SOX13 using radioligand assays, and testing for genetic mutations associated with MODY3\/MODY6 and mitochondrial diabetes. Mutations of HNF\u20101\u03b1 (MODY3) and neuroD1\/\u03b22 (MODY6) genes were screened using the single\u2010strand conformation polymorphism (SSCP) technique and sequencing. Mitochondrial DNA mutations were analysed with polymerase chain reaction\u2014restriction fragment length polymorphism (PCR\u2010RFLP).<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Within the cohort, we found one patient with a novel mutation, R321H (CGC\u2192CAC) in exon\u00a05 of the HNF\u20101\u03b1 gene, one with ND1 mt3316 G\u2192A mutation in mitochondrial DNA, five with Ala45Thr polymorphisms in the neuroD1\/\u03b22 gene, and two patients with autoantibodies to SOX13.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Some of the Chinese patients originally thought to have Type\u00a01B diabetes do have other evidence of islet autoimmunity and genetic mutations involved in the underlying aetiology. This suggests that more rigorous screening for these conditions is needed before classifying subjects as having Type\u00a01B diabetes.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2005.01722.x","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T11:44:01Z","timestamp":1124970241000},"page":"67-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Islet autoimmunity and genetic mutations in Chinese subjects initially thought to have Type\u00a01B diabetes"],"prefix":"10.1111","volume":"23","author":[{"given":"D.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,22]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930290016628"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00273.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.6.1269"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.333"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051204"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.331"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199712)14:12<1026::AID-DIA514>3.0.CO;2-M"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.416"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.876"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.8.1438"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)10014-1"},{"key":"e_1_2_8_15_2","first-page":"82","article-title":"Detection of GAD Ab index in diabetic patients using 35S labeled recombinant human GAD65 antigen","volume":"23","author":"Huang G","year":"2003","journal-title":"Chin J Nucl Med"},{"key":"e_1_2_8_16_2","first-page":"18","article-title":"The radioligand assay of protein tyrosine phosphatase autoantibody and clinical implications","volume":"12","author":"Huang G","year":"2004","journal-title":"Chin J Diabetes"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978796"},{"key":"e_1_2_8_18_2","first-page":"549","article-title":"Diagnostic value of carboxypeptidase H autoantibodies in detecting latent autoimmune diabetes in adults","volume":"28","author":"Zhou Z","year":"2003","journal-title":"Bull Hunan Med University"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930108995994"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1550"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0324"},{"key":"e_1_2_8_22_2","unstructured":"Boyce\u2010JacinoMT SantamariaP LindstromAL BarbosaJJ FarasAJ RichSS.HLA typing by direct sequencing analysis. 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