{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:15:23Z","timestamp":1791850523367,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T00:00:00Z","timestamp":1161129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes where correct diagnosis alters treatment, prognosis and genetic counselling. The first UK survey of childhood MODY identified 20 White, but no Asian children with MODY. We hypothesized that MODY causes diabetes in UK Asians, but is underdiagnosed.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Children with dominant family histories of diabetes were recruited. Direct sequencing for mutations in the two most common MODY genes; <jats:italic>HNF1A (TCF1)<\/jats:italic> and <jats:italic>GCK<\/jats:italic> was performed in autoantibody\u2010negative probands. We also compared MODY testing data for Asian and White cases from the Exeter MODY database, to 2001 UK census data.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> We recruited 30 families and identified three Asian families with MODY gene mutations (two <jats:italic>HNF1A<\/jats:italic>, one <jats:italic>GCK<\/jats:italic>) and three White UK families (two <jats:italic>HNF1A<\/jats:italic>, one <jats:italic>GCK<\/jats:italic>). Heterozygous MODY phenotypes were similar in Asians and Whites. Only eight (0.5%) of 1369 UK referrals for MODY testing were known to be Asian, but in 2001 Asians represented 4% of the English\/Welsh population and have a higher prevalence of diabetes.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> We identified three cases of childhood MODY in UK Asians and demonstrated reduced rates of MODY testing in Asians, which has negative implications for treatment. It is unclear why this is. MODY should be considered in autoantibody\u2010negative Asian diabetes patients lacking evidence of insulin resistance.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2006.01958.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T19:40:12Z","timestamp":1161200412000},"page":"1257-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Asian MODY: are we missing an important diagnosis?"],"prefix":"10.1111","volume":"23","author":[{"given":"J. R.","family":"Porter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Rangasami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ellard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Gloyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Hattersley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Frayling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Plunkett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.24.1.44"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00409.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00530.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031282"},{"key":"e_1_2_8_6_2","unstructured":"VenkatesanR EkJ PedersenO ViswanathanM TorbenH.Identification of Novel Mutations in the HNF\u20101alpha Gene in South Indian Patients with Maturity Onset Diabetes of the Young.1\u20106\u2010 2004. ADA Meeting abstracts.2004."},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.220"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.43.5.730"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402280"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00285.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.524b"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.027821"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00543.x"},{"key":"e_1_2_8_14_2","volume-title":"Census Report 2001","author":"Statistics OoN.","year":"2001"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1701"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2007.S101"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.09.008"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442104"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.11.2854"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91164-P"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00002950"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00691.x"},{"key":"e_1_2_8_23_2","first-page":"25","volume-title":"19th Annual Report.","author":"British Paediatric Surveillance Unit.","year":"2005"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2001"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00447.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2003.08.004"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00305.x"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.11.3191-a"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/ann.34.3.207.217"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.1.89"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2006.01958.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2006.01958.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:57:08Z","timestamp":1696881428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2006.01958.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,18]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1464-5491.2006.01958.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2006.01958.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,18]]},"assertion":[{"value":"2006-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}