{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T06:26:03Z","timestamp":1772346363927,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T00:00:00Z","timestamp":1161129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To assess insulin sensitivity and secretion in the fasting state in regularly transfused patients with \u03b2\u2010thalassaemia major with normal glucose response during an oral glucose tolerance test and to estimate its possible relation to iron overload.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> We measured fasting glucose, insulin and C\u2010peptide levels in 24 patients with \u03b2\u2010thalassaemia major and 18 control subjects matched for age and body mass index. Insulin sensitivity and insulin release index were calculated according to the homeostasis model assessment (HOMA). Correlations with age, body mass index and serum ferritin were also calculated.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Fasting glucose levels in patients were increased compared with control subjects (5.5\u00a0\u00b1\u00a00.12 vs. 4.7\u00a0\u00b1\u00a00.13\u00a0mmol\/l, mean\u00a0\u00b1\u00a0<jats:sc>sem<\/jats:sc>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Pancreatic B\u2010cell insulin secretion in the fasting state (estimated by SC<jats:sub>HOMA<\/jats:sub>) was lower in thalassaemic patients (SC<jats:sub>HOMA<\/jats:sub> 88.5\u00a0\u00b1\u00a011.11 vs. 184.3\u00a0\u00b1\u00a023.72 in control subjects, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patients were then divided into those with impaired (IFG) and normal (NFG) fasting glucose. SC<jats:sub>HOMA<\/jats:sub> was higher in the patients with NFG compared with those with IFG patients (110.6\u00a0\u00b1\u00a017.63 vs. 66.3\u00a0\u00b1\u00a010.88, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) but estimated insulin sensitivity (ISI<jats:sub>HOMA<\/jats:sub>) was similar. Plasma values of C\u2010peptide correlated positively with ferritin (<jats:italic>r\u00a0=<\/jats:italic>\u00a00.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and SC<jats:sub>HOMA<\/jats:sub> (<jats:italic>r\u00a0=<\/jats:italic>\u00a00.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and negatively with ISI<jats:sub>HOMA<\/jats:sub> (<jats:italic>r\u00a0=<\/jats:italic>\u00a0\u22120.43, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> These results support the concept that impaired B\u2010cell function, as reflected by a reduction in the insulin secretion index, is present in \u03b2\u2010thalassaemic patients with normoglycaemia before changes in oral glucose tolerance tests are apparent.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2006.01988.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T10:49:06Z","timestamp":1161168546000},"page":"1327-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Reduced insulin secretion in normoglycaemic patients with \u03b2\u2010thalassaemia major"],"prefix":"10.1111","volume":"23","author":[{"given":"N. 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