{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:20:35Z","timestamp":1762176035898},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> To determine the prognosis of patients with Type\u00a01 or Type\u00a02 diabetes, 6\u00a0years after screening for silent myocardial ischaemia (SMI).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Two hundred and three asymptomatic patients with diabetes underwent systematic SMI screening. From the results of this screening, they were allocated to one of three groups: patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0171) with negative screening; patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) with positive screening; and patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) with positive screening and coronary stenosis. Six years after the initial assessment, all patients were re\u2010assessed. All events [death, cardiac death, non\u2010fatal major cardiac events (NFMCEs)\u2014acute myocardial infarction, ventricular rhythm disorders, heart failure, unstable angina] were recorded.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fifteen patients were lost to follow\u2010up. Patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) with positive SMI screening and coronary stenosis had a higher risk of NFMCEs (35% vs. 7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and a higher mortality rate (35% vs. 15%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) compared with patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0157) with negative screening. SMI\u2010positive patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) had a higher NFMCE rate compared with negative SMI screening patients, although overall mortality rate was no different. Cancer was the leading cause of death (36.4%). In multivariate analysis, major cardiac events (cardiac death and NFMCE) were related to baseline age, body mass index and coronary stenosis (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Patients with diabetes and SMI have a very poor prognosis as assessed by cardiac events or death, especially in the presence of coronary stenosis.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2006.01992.x","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T10:32:16Z","timestamp":1158575536000},"page":"1186-1191","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Six\u2010year follow\u2010up of a cohort of 203 patients with diabetes after screening for silent myocardial ischaemia"],"prefix":"10.1111","volume":"23","author":[{"given":"S.","family":"Sejil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Janand\u2010Delenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010F.","family":"Avierinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Labastie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Raccah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Lassmann\u2010Vague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"446","article-title":"Coronary disease and diabetes","volume":"21","author":"Passa P","year":"1995","journal-title":"Diabetes Metabolism"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1551"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013952.86046.DD"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(04)72800-1"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02702-9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.1797"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1074"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.339"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1396"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.2032"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.02.013"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1313"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.19"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-2-170"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1134"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.7.1138"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118498.35499.B2"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013955.34262.AF"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-7-200404060-00001"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.548461"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of randomized trials of anti\u2010platelet therapy. 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