{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:22:42Z","timestamp":1780438962697,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T00:00:00Z","timestamp":1170028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> To determine whether mild alcohol intoxication (45\u201350\u00a0mg\/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8\u00a0mmol\/l) in patients with Type 1 diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Seventeen subjects (14 male, age range 21\u201346\u00a0years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4\u00a0g\/kg); hypoglycaemia (2.8\u00a0mmol\/l for 65\u00a0min) with placebo; and hypoglycaemia (2.8\u00a0mmol\/l for 65\u00a0min) with alcohol (0.4\u00a0g\/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> During hypoglycaemia, peak growth hormone concentrations were significantly lower after alcohol compared with placebo (14.3\u00a0\u00b1\u00a02.9 vs. 25.9\u00a0\u00b1\u00a03.4\u00a0\u00b5g\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) associated with reduced insulin sensitivity in both hypoglycaemia and euglycaemia studies.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> We found an attenuated growth hormone response to hypoglycaemia associated with mild alcohol intoxication. Although this may potentially contribute to impaired recovery of glucose after hypoglycaemia in patients with Type 1 diabetes, it appears to be offset by a reduction in insulin action.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2006.02054.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T18:20:44Z","timestamp":1170440444000},"page":"312-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes"],"prefix":"10.1111","volume":"24","author":[{"given":"D.","family":"Kerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Cheyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sherwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404799"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01154.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.1888"},{"key":"e_1_2_7_5_2","first-page":"253","volume-title":"Hypoglycaemia and Diabetes: Clinical and Physiological Aspects.","author":"Gerich JE","year":"1993"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403293101302"},{"key":"e_1_2_7_7_2","first-page":"58","article-title":"Effect of ethanol on spontaneous and stimulated growth hormone secretion","volume":"18","author":"Redmond GP","year":"1981","journal-title":"Prog Biochem Pharmacol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.3.796"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.11.1626"},{"key":"e_1_2_7_10_2","first-page":"E175","article-title":"Acute effects of ethanol and acetate on glucose kinetics in normal subjects","volume":"254","author":"Yki\u2010Jarvinnen H","year":"1988","journal-title":"Am J Physiol"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2006.02054.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2006.02054.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:37:25Z","timestamp":1696894645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2006.02054.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,14]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1464-5491.2006.02054.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2006.02054.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,14]]},"assertion":[{"value":"2007-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}