{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:15:52Z","timestamp":1785233752063,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T00:00:00Z","timestamp":1169769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine whether pancreatic B\u2010cell function varies in different populations with similar genetic backgrounds but different environments.<\/jats:p><jats:p><jats:bold>Research design\/methods\u2002<\/jats:bold> We compared a specific migrant Gujarati community in the UK (<jats:italic>n<\/jats:italic>\u00a0=\u00a0205) with people still resident in the same villages of origin in Gujarat, India (<jats:italic>n<\/jats:italic>\u00a0=\u00a0246). Pancreatic B\u2010cell function (HOMA\u2010B) was determined and the influence of age, migration and other factors was explored.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> As anticipated, there was an age\u2010related decline in log(HOMA\u2010B) in both groups. However, the age\u2010related fall in log(HOMA\u2010B) was more pronounced in the UK than in Gujarat (normalized \u03b2\u22120.29 vs. \u22120.14, <jats:italic>P<\/jats:italic> for difference\u00a0=\u00a00.03). The decline of HOMA\u2010B with age persisted after adjustment for body mass index (UK \u03b2\u00a0=\u00a0\u22120.31; Gujarat \u03b2\u00a0=\u00a0\u22120.16, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was no significant change in insulin sensitivity (HOMA\u2010S) with age at either site, although insulin sensitivity was lower in the UK. Fasting non\u2010estrified fatty acid (NEFA) levels rose with age in the UK but not in Gujarat (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.003 for difference in gradients). In multiple linear regression analysis, lower log(HOMA\u2010B) was independently associated with higher fasting log(NEFA) levels; normalized \u03b2\u00a0=\u00a0\u22120.24, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, age; \u03b2\u00a0=\u00a0\u22120.16, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005, higher log(insulin\u2010like growth factor binding protein\u20101); \u03b2\u00a0=\u00a0\u22120.19, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007 and lower body mass index; \u03b2\u00a0=\u00a00.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001. This model accounted for 25% of the variability in HOMA\u2010B.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> HOMA\u2010B as a measure of B\u2010cell function declines more rapidly with age in the migrant UK group than in Gujarat. This may be a direct consequence of chronically higher NEFA exposure in the UK group.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2007.02032.x","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T17:27:35Z","timestamp":1169832455000},"page":"145-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Change in pancreatic B\u2010cell function (HOMA\u2010B) varies in different populations with similar genetic backgrounds but different environments"],"prefix":"10.1111","volume":"24","author":[{"given":"A. H.","family":"Heald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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