{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:35:55Z","timestamp":1759991755629},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> The purpose of the study was to determine long\u2010term cardiovascular autonomic adaptation to moderate endurance aerobic exercise in people with Type 2 diabetes in order to test the hypothesis of an enhanced vagal drive.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We analysed the power spectral density of heart rate cyclic variations at rest, while lying, and while standing in 12 sedentary, non\u2010smoking, Type 2 diabetic individuals. Testing was performed before and after a 6\u2010month, supervised, progressive, aerobic training programme, twice weekly. Heart rate variability was assessed by autoregressive power spectral analysis (PSA); this method allows reliable quantification of low\u2010frequency (LF) and high\u2010frequency (HF) components, which are considered to be under mainly sympathetic and purely parasympathetic control, respectively.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In 10\u2010min electrocardiogram recordings, mean RR intervals values lying and standing were similar before and after physical exercise. Likewise, total heart rate variability, expressed as total power spectral density (PSD), was not altered by exercise. In contrast, on standing, the HF component, expressed in normalized units, was significantly higher (20.1\u00a0\u00b1\u00a04 vs. 30.4\u00a0\u00b1\u00a05, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), whereas the LF component was significantly lower (68.1\u00a0\u00b1\u00a07 vs. 49.8\u00a0\u00b1\u00a08, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) after exercise; hence, on standing, the LF\/HF ratio, reflecting the sympathetic vs. parasympathetic balance, was markedly lower (16.2\u00a0\u00b1\u00a011 vs. 5.2\u00a0\u00b1\u00a03.2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). No significant exercise\u2010related changes in these PSA components were observed on lying.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> A twice\u2010weekly, 6\u2010month, moderate, aerobic exercise programme, without a concomitant weight loss diet, is associated with significant improvements in cardiovascular autonomic function in overweight, non\u2010smoking, Type 2 diabetic individuals.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2007.02076.x","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:18:08Z","timestamp":1172708288000},"page":"370-376","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effect of moderate aerobic exercise on sympatho\u2010vagal balance in Type 2 diabetic patients"],"prefix":"10.1111","volume":"24","author":[{"given":"G.","family":"Zoppini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cacciatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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