{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:13:34Z","timestamp":1759482814442},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,11]],"date-time":"2007-06-11T00:00:00Z","timestamp":1181520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To analyse the risk factors for the development of micro\u2010 and macroalbuminuria and mortality rates in a cohort of normoalbuminuric Type\u00a02 diabetes mellitus (DM) patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this prospective study, 193 Type\u00a02 DM patients with urinary albumin excretion (UAE)\u00a0&lt;\u00a020\u00a0\u00b5g\/min, 96 men (50%), aged 56.5\u00a0\u00b1\u00a09\u00a0years, were followed for a mean period of 8\u00a0\u00b1\u00a03\u00a0years. UAE and estimated glomerular filtration rate (eGFR; Modification of Diet in Renal Disease) were measured. The outcomes were development of persistent micro\u2010 and macroalbuminuria and mortality.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty patients were lost to follow\u2010up. Of the 173 remaining patients, 33 (19%) died. The Cox analysis [hazard ratio (HR), 95% confidence interval] revealed that the baseline significant predictors of mortality were higher UAE [above median (5\u00a0\u00b5g\/min); HR\u00a02.7, 1.2\u20136.1; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02], male sex (HR\u00a0 3.9, 1.7\u20139.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), age (HR\u00a01.6, 1.3\u20131.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), and fasting plasma glucose (HR\u00a01.2, 1.1\u20131.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Smoking and eGFR were not significant in this model. Follow\u2010up renal data were available for 158 patients: 34 (22%) progressed to microalbuminuria and seven (4%) to macroalbuminuria, and the baseline predictors were a higher UAE (&gt;\u00a05\u00a0\u00b5g\/min, HR\u00a02.5, 1.2\u20135.1; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), presence of diabetic retinopathy (HR\u00a02.5, 1.3\u20135.0; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), fasting glucose (HR\u00a01.1, 1.0\u20131.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015), and male sex (HR\u00a02.2, 1.1\u20134.7; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), independently of smoking and hypertension. Lower GFR (HR\u00a00.98, 0.97\u20131.00; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) was of borderline significance.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In normoalbuminuric Type\u00a02 DM patients, the development of micro\u2010 or macroalbuminuria and mortality rates was independently and positively associated with higher levels of albuminuria, although still in the traditionally established normal range.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2007.02209.x","type":"journal-article","created":{"date-parts":[[2007,6,11]],"date-time":"2007-06-11T13:42:06Z","timestamp":1181569326000},"page":"1136-1142","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["High\u2010normal levels of albuminuria predict the development of micro\u2010 and macroalbuminuria and increased mortality in Brazilian Type\u00a02 diabetic patients: an 8\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"Murussi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Campagnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. O.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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