{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:41:55Z","timestamp":1744180915933},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T00:00:00Z","timestamp":1219017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> In Type\u00a01 diabetes mellitus (DM), it has been suggested that autonomic nervous system dysfunction (NAD) impairs lung diffusion capacity. Heart rate variability (HRV), a measure of cardiac autonomic function, is a sensitive method of detecting NAD. To our knowledge, no previous study has assessed whether cardiac sympatho\u2010vagal balance is associated with lung diffusion capacity in diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Twenty Type\u00a01 DM patients without pulmonary abnormalities and systemic NAD underwent measurement of lung diffusion capacity for carbon monoxide (DLCO) by single\u2010breath method and assessment of cardiac autonomic function by HRV analysis on 24\u2010h electrocardiographic Holter recordings.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Standard respiratory function tests and peripheral autonomic tests were normal in all patients. DLCO was lower than normal reference values in six patients (30%). DLCO correlated significantly with most HRV variables, independent of the clinical and laboratory variables. The strongest correlation was found with standard deviation of all RR intervals (SDNN; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.62, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) in the time domain and low frequency (LF) power (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.73, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the frequency domain.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> In Type\u00a01 diabetes, a significant association exists between cardiac NAD and reduced DLCO in the absence of clinical respiratory and autonomic abnormalities. Thus, NAD may be involved in the early reduction of DLCO in these patients, possibly through abnormalities in the regulation of pulmonary blood flow at the microvascular level.<\/jats:p>","DOI":"10.1111\/j.1464-5491.2008.02571.x","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T16:40:03Z","timestamp":1219077603000},"page":"1366-1369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between reduced pulmonary diffusing capacity and cardiac autonomic dysfunction in Type\u00a01 diabetes"],"prefix":"10.1111","volume":"25","author":[{"given":"D.","family":"Pitocco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Santangeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zaccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Longobardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Infusino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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