{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:38:49Z","timestamp":1768419529351,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T00:00:00Z","timestamp":1272844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 27, 812\u2013822 (2010)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> For selected individuals with complex Type 1 diabetes, pancreatic islet transplantation (IT) offers the potential of excellent glycaemic control without significant hypoglycaemia, balanced by the need for ongoing systemic immunosuppression. Increasingly, patient\u2010reported outcomes (PROs) are considered alongside biomedical outcomes as a measure of transplant success. PROs in IT have not previously been compared directly with the closest alternate treatment option, pancreas transplant alone (PTA) or pancreas after kidney (PAK).<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> We used a Population, Intervention, Comparisons, Outcomes (PICO) strategy to search Scopus and screened 314 references for inclusion.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Twelve studies [including PRO assessment of PAK, PTA, islet\u2010after kidney (IAK) and islet transplant alone (ITA); <jats:italic>n<\/jats:italic>\u2003=\u20037\u2013205] used a total of nine specified and two unspecified PRO measures. Results were mixed but identified some benefits which remained apparent up to 36 months post\u2010transplant, including improvements in fear of hypoglycaemia, as well as some aspects of diabetes\u2010specific quality of life (QoL) and general health status. Negative outcomes included short\u2010term pain associated with the procedure, immunosuppressant side effects and depressed mood associated with loss of graft function.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> The mixed results may be attributable to limited sample sizes. Also, some PRO measures may lack sensitivity to detect actual changes, as they exclude issues and domains of life likely to be important for QoL post\u2010transplantation and when patients may no longer perceive themselves to have diabetes. Thus, the full impact of islet\/pancreas transplantation (alone or after kidney) on QoL is unknown. Furthermore, no studies have assessed patient satisfaction, which may highlight further advantages and disadvantages of transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2010.03029.x","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T06:37:08Z","timestamp":1272955028000},"page":"812-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Patient\u2010reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type\u20031 diabetes: a systematic review"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Speight","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Reaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Woodcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,30]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511543579.246"},{"key":"e_1_2_9_3_2","volume-title":"Islet Transplantation in Patients with Type\u20031 Diabetes Mellitus","author":"Piper M","year":"2004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.306.5693.34"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.1.112"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2060"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-008-0057-3"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mot.0000163355.12317.37"},{"key":"e_1_2_9_10_2","unstructured":"National Institute for Clinical Excellence (NICE)2008.Interventional Procedure Consultation Document: Allogeneic pancreatic islet cell transplantation for type\u20031 diabetes mellitus. Available athttp:\/\/guidance.nice.org.uk\/IPG257\/Guidance\/pdf\/EnglishLast accessed 18 May 2010."},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000160816.21799.F5"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02731.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00676-6"},{"key":"e_1_2_9_14_2","first-page":"1342","article-title":"Duct occlusion\u2010induced vascularized islet grafts are not associated with progressive long\u2010term dysfunction","volume":"27","author":"Illner WD","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.09.008"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318166a27b"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01174.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31818a7f45"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000187881.97068.77"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200104000-00003"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.01.001"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000280550.01028.89"},{"key":"e_1_2_9_23_2","first-page":"321","article-title":"Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure","volume":"29","author":"Endicott J","year":"1993","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.9.725"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.5.617"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_9_28_2","volume-title":"Health Status Questionnaire (HSQ) 2.0 Scoring Comparisons and Reference Data","author":"Radosenick DM","year":"1994"},{"key":"e_1_2_9_29_2","volume-title":"Quality of Life and Pharmacoeconomics in Clinical Trials","author":"Feeny D","year":"1996"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.3.187"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(75)90044-5"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1348\/135910702320645381"},{"key":"e_1_2_9_33_2","first-page":"S189","article-title":"Expectations and experiences of transplant: a qualitative study of people with Type\u20031 diabetes undergoing pancreatic islet transplantation","volume":"24","author":"Speight J","year":"2009","journal-title":"Diabet Med"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2010.03029.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2010.03029.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T04:50:28Z","timestamp":1698641428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2010.03029.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,30]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1111\/j.1464-5491.2010.03029.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2010.03029.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,30]]},"assertion":[{"value":"2010-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}