{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:25:54Z","timestamp":1792596354972,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T00:00:00Z","timestamp":1278288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Diabet. Med. 27, 1168\u20131173 (2010)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Aims\u2002<\/jats:bold>\n                      Transient nausea and, to a lesser extent, vomiting are common adverse effects of exenatide that can be mitigated by dose titration and usually do not result in treatment discontinuation. This retrospective analysis of data from a phase\u20031, open\u2010label, parallel\u2010group, single\u2010dose study in healthy subjects evaluated the effect of oral anti\u2010emetics on exenatide\u2010associated nausea and vomiting and on the pharmacokinetics of exenatide.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods\u2002<\/jats:bold>\n                      A single subcutaneous dose (10\u2003\u03bcg) of exenatide was administered to 120 healthy subjects (19\u201365\u2003years, BMI 23\u201335\u2003kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Incidences of nausea and vomiting were compared between 60 subjects premedicated with two oral anti\u2010emetics 30\u2003min before the exenatide dose and 60\u2003non\u2010premedicated subjects. Similarly, the area under the concentration\u2010time curve (AUC) and the maximum observed concentration (C\n                      <jats:sub>max<\/jats:sub>\n                      ) of plasma exenatide concentrations over 8\u2003h post\u2010dose were compared.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results\u2002<\/jats:bold>\n                      Among all subjects [61% male, 32\u2003\u00b1\u200312\u2003years, body mass index (BMI) 29.1\u2003\u00b1\u20033.4\u2003kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (mean\u2003\u00b1\u2003\n                      <jats:sc>sd<\/jats:sc>\n                      )], mild to moderate nausea was the most frequent adverse event after exenatide dosing. Vomiting was also observed. Subjects premedicated with anti\u2010emetics experienced significantly less nausea and vomiting (16.7 and 6.7%, respectively) vs. non\u2010premedicated subjects (61.7 and 38.3%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value &lt;\u20030.0001 for both nausea and vomiting). The mean area under the concentration\u2010time curve and the maximum observed concentration AUC and C\n                      <jats:sub>max<\/jats:sub>\n                      of plasma exenatide concentrations during 8\u2003h post\u2010dose were not significantly different between groups.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusion\u2002<\/jats:bold>\n                      Administration of oral anti\u2010emetics before a single 10\u2010\u03bcg exenatide dose was associated with significant reductions in treatment\u2010emergent nausea and vomiting, with no discernible effect on the pharmacokinetics of exenatide. Use of anti\u2010emetic therapy may provide a short\u2010term strategy to minimize the nausea and vomiting associated with exenatide treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-5491.2010.03085.x","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T20:24:40Z","timestamp":1278447880000},"page":"1168-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Prophylactic use of anti\u2010emetic medications reduced nausea and vomiting associated with exenatide treatment: a retrospective analysis of an open\u2010label, parallel\u2010group, single\u2010dose study in healthy subjects"],"prefix":"10.1111","volume":"27","author":[{"given":"C.","family":"Ellero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhavsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. B.","family":"Cirincione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"DeYoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Yushmanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,5]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"BYETTA\u00ae exenatide injection (prescribing information)","author":"Amylin Pharmaceuticals Inc","year":"2009"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.08.006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1083"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.11.2628"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1092"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-7-200704030-00003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.499"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145721706298435"},{"key":"e_1_2_7_10_2","volume-title":"Reglan\u00ae metoclopramide hydrochloride tablets (prescribing information)","author":"Alaven Pharmaceutical LLC","year":"2009"},{"key":"e_1_2_7_11_2","volume-title":"Zofran (ondansetron hydrochloride) tablets (prescribing information)","author":"GlaxoSmithKline","year":"2009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145721706287653"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X253870"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2010.03085.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2010.03085.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T11:55:24Z","timestamp":1698753324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2010.03085.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,5]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1111\/j.1464-5491.2010.03085.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2010.03085.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,5]]},"assertion":[{"value":"2010-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}