{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:56:10Z","timestamp":1768276570519,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T00:00:00Z","timestamp":1279670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 27, 1308\u20131311 (2010)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> The reported prevalence of Type\u20032 diabetes mellitus in patients with liver cirrhosis is five times higher than in the general population. However, these data were never adjusted for classical risk factors for Type\u20032 diabetes. We therefore investigated the association between cirrhosis and Type\u20032 diabetes and adjusted for known risk factors for Type\u20032 diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We reviewed medical files for presence of Type\u20032 diabetes and potential confounders in 94 patients with cirrhosis (cases) and compared these with a control group of 107 patients with non\u2010ulcer dyspepsia. Multiple logistic regression analysis was used to adjust for potential confounders.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The aetiology of our cirrhosis population was alcohol (59%), viral hepatitis (10%), biliary cirrhosis (3%) or cryptogenic (28%). Prevalence of Type\u20032 diabetes was significantly higher in patients with cirrhosis than in control subjects: 35\/94 (37%) vs. 7\/107 (7%) (OR 8.5, 95% CI 3.5\u201320.2, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). After adjustment for age, sex, family history of Type\u20032 diabetes, alcohol use and BMI, cirrhosis remained significantly associated with Type\u20032 diabetes (OR 13.6, 95% CI 4.3\u201342.9, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Most cases of Type\u20032 diabetes were already diagnosed before diagnosis of cirrhosis (21\/35, 60%) or were incidentally found together with cirrhosis (5\/35, 14%).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Liver cirrhosis had a strong, independent association with Type\u20032 diabetes. Classical risk factors such as family history and BMI could not explain the high Type\u20032 diabetes prevalence in cirrhosis. Therefore, a liver\u2010derived factor might aggravate glucose intolerance and cause Type\u20032 diabetes in cirrhosis. In addition, Type\u20032 diabetes might also cause cirrhosis through liver steatosis and fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2010.03093.x","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T20:03:34Z","timestamp":1279742614000},"page":"1308-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["High prevalence of diabetes mellitus in patients with liver cirrhosis"],"prefix":"10.1111","volume":"27","author":[{"given":"N.","family":"Wlazlo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J. B. H.","family":"Beijers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Schoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Sauerwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D. A.","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bravenboer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90334-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02755.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-4-4"},{"key":"e_1_2_6_5_2","first-page":"476","article-title":"Glycemic homeostasis in chronic viral hepatitis and liver cirrhosis","volume":"27","author":"Custro N","year":"2001","journal-title":"Diabetes Metab"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80065-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.17894"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4771"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(93)90130-W"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190312"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115340"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1171"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-1995"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03112.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290347"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00143-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2509"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432007"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.7.815"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320309"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070124"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S304"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.15.1676"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.12.015"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.636"},{"key":"e_1_2_6_28_2","first-page":"1052","article-title":"Diabetes mellitus in the Netherlands: estimate of the current disease burden and prognosis for 2025","volume":"153","author":"Baan CA","year":"2009","journal-title":"Ned Tijdschr Geneeskd"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1464-5491.2010.03093.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1464-5491.2010.03093.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:18:58Z","timestamp":1698725938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1464-5491.2010.03093.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,21]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1464-5491.2010.03093.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1464-5491.2010.03093.x","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,21]]},"assertion":[{"value":"2010-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}