{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:57:48Z","timestamp":1787014668543,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T00:00:00Z","timestamp":1313366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Diabet. Med. 28, 1018\u20131027 (2011)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Aims\u2002<\/jats:bold>\n                      To test whether the\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      gene was associated with gestational diabetes, whether the association between\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      and gestational diabetes was independent of HLA\u2010DQB1*0602 and islet cell autoantibodies, as well as maternal age, number of pregnancies, family history of diabetes and the HLA\u2010DQB1 genotypes, and to test whether the distribution of HLA\u2010DQB1 alleles was affected by country of birth.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods\u2002<\/jats:bold>\n                      We genotyped the rs7903146, rs12255372 and rs7901695 single nucleotide polymorphisms of the\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      gene in 826 mothers with gestational diabetes and in 1185 healthy control subjects in the Diabetes Prediction in Sk\u00e5ne Study. The mothers were also typed for HLA\u2010DQB1 genotypes and tested for islet cell autoantibodies against GAD65, insulinoma\u2010associated antigen\u20102 and insulin.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results\u2002<\/jats:bold>\n                      The heterozygous genotypes CT, GT and TC of the rs7903146 (T is risk for Type\u20032 diabetes), rs12255372 (T is risk for Type\u20032 diabetes) and rs7901695 (C is risk for Type\u20032 diabetes), respectively, as well as the homozygous genotypes TT, TT and CC of the rs7903146, rs12255372 and rs7901695, respectively, were strongly associated with gestational diabetes (\n                      <jats:italic>P\u2003<\/jats:italic>\n                      &lt;\u20030.0001). These associations remained statistically significant after adjusting for maternal age, number of pregnancies, family history of diabetes and HLA\u2010DQ genotypes and were independent of the presence of islet cell autoantibodies. No interaction was observed between\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      and HLA\u2010DQB1*0602, which was shown to be negatively associated with gestational diabetes in mothers born in Sweden (\n                      <jats:italic>P\u2003<\/jats:italic>\n                      =\u20030.010).\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusions\u2002<\/jats:bold>\n                      The\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      was associated with susceptibility for gestational diabetes independently of the presence of HLA\u2010DQB1*0602 and islet cell autoantibodies and other factors such as maternal age, number of pregnancies, family history of diabetes and other HLA\u2010DQ genotypes. The HLA\u2010DQB1*0602 was negatively associated with gestational diabetes in mothers born in Sweden.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03359.x","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T23:43:27Z","timestamp":1308095007000},"page":"1018-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA\u2010DQB1*0602 genotypes and islet cell autoantibodies"],"prefix":"10.1111","volume":"28","author":[{"given":"A.","family":"Papadopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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