{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:38:19Z","timestamp":1715596699301},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label \/><jats:p>Diabet. Med. 29, 80\u201387 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2003<\/jats:bold> Orthostatic hypotension is a hallmark of diabetic autonomic neuropathy and is associated with increased mortality. The serum level of adiponectin is elevated in patients with heart failure or renal failure. In the present study, we measured serum levels of total and high molecular weight adiponectin in patients with Type\u20032 diabetes and orthostatic hypotension. We also investigated the relationship between the presence of orthostatic hypotension and various clinical variables in patients with Type\u20032 diabetes.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> We studied 105 patients with Type\u20032 diabetes. Orthostatic hypotension was defined as a decrease of 20\u2003mmHg or more in systolic blood pressure and\/or 10\u2003mmHg in diastolic blood pressure when blood pressure was measured for 3\u2003min while standing. The brachial\u2013ankle pulse\u2010wave velocity was also measured as an index of arterial stiffness.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Orthostatic hypotension was found in 30 patients with diabetes (28.6%). The haematocrit and estimated glomerular filtration rate were significantly lower in patients with orthostatic hypotension than in those without it. Brachial\u2013ankle pulse\u2010wave velocity and serum total and high molecular weight adiponectin were significantly higher in patients with orthostatic hypotension than in those without. Furthermore, the high molecular weight\/total adiponectin ratio was higher in patients with orthostatic hypotension than in those without and hypertension was more common in patients with orthostatic hypotension. Plasma prothrombin F1\u2003+\u20032, a coagulation maker, was higher in patients with orthostatic hypotension than in those without, while there were no differences of fibrinolytic markers between the two groups. Multivariate analysis showed that HDL cholesterol, haematocrit, F1\u2003+\u20032, brachial\u2013ankle pulse\u2010wave velocity and a decline of systolic blood pressure on standing were independent determinants of high molecular weight adiponectin.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Patients with Type\u20032 diabetes and orthostatic hypotension had an elevated serum level of high molecular weight adiponectin, which was associated with the simultaneous presence of renal dysfunction, anaemia, arterial stiffness and hypercoagulability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03364.x","type":"journal-article","created":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T17:09:14Z","timestamp":1321290554000},"page":"80-87","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Elevation of serum high molecular weight adiponectin in patients with Type\u20032 diabetes and orthostatic 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