{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:30:07Z","timestamp":1774686607008,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetic Medicine"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Diabet. Med. 29, 121\u2013127 (2012)<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> Recent genome\u2010wide association studies have identified several Type\u20032 diabetes\u2010related loci. We investigated the effect of susceptibility genetic variants, individually, together and in combination with conventional risk factors, on Type\u20032 diabetes and diabetes\u2010related traits in Indians.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> We genotyped 33 variants in 1808 Indian patients and 1549 control subjects and performed association analyses with Type\u20032 diabetes and related traits using an additive model for individual variant and for genetic risk score based on 32 polymorphisms. The discriminatory value of genetic risk over conventional risk factors was analysed using receiver\u2010operating characteristics curve analysis.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The allelic odds ratio ranged from 1.01 (95%\u2003CI 0.85\u20131.19) to 1.66 (95%\u2003CI 1.32\u20132.01) for single\u2010variant analyses. Although, only 16 variants had significant odds ratios, the direction of association for others was similar to earlier reports. The odds ratio for Type\u20032 diabetes at each genetic risk score point was 1.11 (95%\u2003CI 1.09\u20131.14; <jats:italic>P<\/jats:italic>\u2003=\u20035.6\u2003\u00d7\u200310<jats:sup>\u221217<\/jats:sup>) and individuals with extremes of genetic risk score (\u2265\u200329.0 and \u2264\u200317.0) had a 7.5\u2010fold difference in risk of Type\u20032 diabetes. The discrimination rate between control subjects and patients improved marginally on addition of genetic risk score to conventional risk factors (area under curve\u2003=\u20030.959 and 0.963, respectively; <jats:italic>P<\/jats:italic>\u2003=\u20030.001). Of all the quantitative traits analysed, <jats:italic>MC4R<\/jats:italic> variants showed strong association with BMI (<jats:italic>P<\/jats:italic>\u2003=\u20034.1\u2003\u00d7\u200310<jats:sup>\u22124<\/jats:sup>), fat mass per cent (<jats:italic>P<\/jats:italic>\u2003=\u20032.4\u2003\u00d7\u200310<jats:sup>\u22124<\/jats:sup>) and other obesity\u2010related traits, including waist circumference and hip circumference (<jats:italic>P<\/jats:italic>\u2003=\u20032.0\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup> for both), as well as insulin resistance (<jats:italic>P<\/jats:italic>\u2003=\u20030.02).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> We replicated the association of well\u2010established common variants with Type\u20032 diabetes in Indians and observed a similar association as reported in Western populations. Combined analysis of 32 variants aids identification of subgroups at increased risk of Type\u20032 diabetes, but adds only a minor advantage over conventional risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1464-5491.2011.03438.x","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T21:33:17Z","timestamp":1315949597000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type\u20032 diabetes and related traits in Indians"],"prefix":"10.1111","volume":"29","author":[{"given":"C. S.","family":"Janipalli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V. K.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Vinay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Sandeep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bhaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aruna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. V.","family":"Joglekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Priyadharshini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Yajnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. R.","family":"Chandak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24758"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05616"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.120"},{"key":"e_1_2_7_6_2","article-title":"Identification of new genetic risk variants for type\u20032 diabetes","volume":"16","author":"Shu XO","year":"2010","journal-title":"PLoS Genet"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000218711"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0117"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1048"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1991.tb01689.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(97)00040-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0502-2"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1186-6"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1386"},{"key":"e_1_2_7_15_2","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. 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